ArticleBiophysical journal2008
Mechanical and biochemical modeling of cortical oscillations in spreading cells.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Excitable RhoA dynamics drive pulsed contractions in the earlyThe Journal of cell biology · 2018Article
- Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape.The Journal of cell biology · 2013Article
- Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries.PLoS computational biology · 2013Article
- Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.Nature communications · 2012Article
- Systems analysis of small signaling modules relevant to eight human diseases.Annals of biomedical engineering · 2011Article
- RhoA regulates calcium-independent periodic contractions of the cell cortex.Biophysical journal · 2010Article
- Calcium-actin waves and oscillations of cellular membranes.Biophysical journal · 2009Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Actomyosin-based cortical contractility is a common feature of eukaryotic cells and is involved in cell motility, cell division, and apoptosis. In nonmuscle cells, oscillations in contractility are induced by microtubule depolymerization during cell spreading. We developed an ordinary differential equation model to describe this behavior. The computational model includes 36 parameters. The values for all but two of the model parameters were taken from experimental measurements found in the literature. Using these values, we demonstrate that the model generates oscillatory behavior consistent with current experimental observations. The rhythmic behavior occurs because of the antagonistic effects of calcium-induced contractility and stretch-activated calcium channels. The model makes several experimentally testable predictions: 1), buffering intracellular calcium increases the period and decreases the amplitude of cortical oscillations; 2), increasing the number or activity of stretch activated channels leads to an increase in period and amplitude of cortical oscillations; 3), inhibiting Ca(2+) pump activity increases the period and amplitude of oscillations; and 4), a threshold exists for the calcium concentration below which oscillations cease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.