ArticleEukaryotic cell2008
Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex.Nature communications · 2026Article
- Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex.Research square · 2025Article
- Article
- Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicateFrontiers in cell and developmental biology · 2023Article
- An altered transcriptome underliesFrontiers in genetics · 2022Article
- TheCells · 2021Review
- Ancient origins of allosteric activation in a Ser-Thr kinase.Science (New York, N.Y.) · 2020Article
- Force balances between interphase centrosomes as revealed by laser ablation.Molecular biology of the cell · 2019Article
- Cytokinesis: Robust cell shape regulation.Seminars in cell & developmental biology · 2016Review
- Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B.The Journal of biological chemistry · 2015Article
- Genetic suppression of a phosphomimic myosin II identifies system-level factors that promote myosin II cleavage furrow accumulation.Molecular biology of the cell · 2014Article
- Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.Open biology · 2013Review
- Cytokinesis mechanics and mechanosensing.Cytoskeleton (Hoboken, N.J.) · 2012Review
- A mechanosensory system governs myosin II accumulation in dividing cells.Molecular biology of the cell · 2012Article
- Article
- A retinoblastoma orthologue is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium.PloS one · 2012Article
- Arabidopsis α Aurora kinases function in formative cell division plane orientation.The Plant cell · 2011Article
- Cytokinesis through biochemical-mechanical feedback loops.Seminars in cell & developmental biology · 2010Review
- 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis.Current biology : CB · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Aurora kinases are highly conserved proteins with important roles in mitosis. Metazoans contain two kinases, Aurora A and B, which contribute distinct functions at the spindle poles and the equatorial region respectively. It is not currently known whether the specialized functions of the two kinases arose after their duplication in animal cells or were already present in their ancestral kinase. We show that Dictyostelium discoideum contains a single Aurora kinase, DdAurora, that displays characteristics of both Aurora A and B. Like Aurora A, DdAurora has an extended N-terminal domain with an A-box sequence and localizes at the spindle poles during early mitosis. Like Aurora B, DdAurora binds to its partner DdINCENP and localizes on centromeres at metaphase, the central spindle during anaphase, and the cleavage furrow at the end of cytokinesis. DdAurora also has several unusual properties. DdAurora remains associated with centromeres in anaphase, and this association does not require an interaction with DdINCENP. DdAurora then localizes at the cleavage furrow, but only at the end of cytokinesis. This localization is dependent on DdINCENP and the motor proteins Kif12 and myosin II. Thus, DdAurora may represent the ancestral kinase that gave rise to the different Aurora kinases in animals and also those in other organisms.
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