ArticleMicrobes and infection2008
Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses.
Article in Microbes and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Animal Models in Eye Research: Focus on Corneal Pathologies.International journal of molecular sciences · 2023Review
- Association of Single-Nucleotide Polymorphisms in Interleukin Genes with Microbial Keratitis in a South Indian Population.Pathogens (Basel, Switzerland) · 2022Article
- A cationic peptide, TAT-Cd°, inhibits herpes simplex virus type 1 ocular infection in vivo.Investigative ophthalmology & visual science · 2013Article
- Article
- ssICAM-1, IL-21 and IL-23 in patients with tick borne encephalitis and neuroborreliosis.Cytokine · 2012Article
- IL-17A differentially regulates corneal vascular endothelial growth factor (VEGF)-A and soluble VEGF receptor 1 expression and promotes corneal angiogenesis after herpes simplex virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Rabbit and mouse models of HSV-1 latency, reactivation, and recurrent eye diseases.Journal of biomedicine & biotechnology · 2012Review
- Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Differences in T-helper polarizing capability between human monocyte-derived dendritic cells and monocyte-derived Langerhans'-like cells.Immunology · 2011Article
- The role of Th17 cytokines in primary mucosal immunity.Cytokine & growth factor reviews · 2010Review
- A crucial role for B and T lymphocyte attenuator in preventing the development of CD4+ T cell-mediated herpetic stromal keratitis.Molecular vision · 2010Article
- A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis.Investigative ophthalmology & visual science · 2010Article
- Immunobiology of herpes simplex virus and cytomegalovirus infections of the fetus and newborn.Current immunology reviews · 2010Article
- Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.Mucosal immunology · 2009Review
- Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.Journal of virology · 2009Article
- Regulation and function of proinflammatory TH17 cells.Annals of the New York Academy of Sciences · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Herpes simplex virus (HSV) infection of the cornea culminates in an immunopathological lesion (stromal keratitis--SK) that impairs vision. This report shows that HSV infection results in IL-23 up-regulation, but if this response fails to occur, as was noted in p19-/- mice, the severity of lesions, their incidence and the level of viral induced angiogenesis were significantly increased compared to wild-type (WT) animals (p<0.05). The higher disease severity in p19-/- mice appeared to be the consequence of an increased IL-12 response that in turn led to the induction of higher numbers of IFN-gamma producing CD4(+)T cells, the principal orchestrators of SK. Our results indicate that the severity of HSV induced immunopathological lesions may be mainly the consequence of IL-12 driven Th1 T cell reactions rather than the action of IL-17 producing cells controlled by IL-23.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.