ArticleJournal of bioinformatics and computational biology2008
A survey on haplotyping algorithms for tightly linked markers.
Article in Journal of bioinformatics and computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- Accurate HLA type inference using a weighted similarity graph.BMC bioinformatics · 2010Article
- Detecting genome-wide haplotype polymorphism by combined use of Mendelian constraints and local population structure.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2010Article
- An almost linear time algorithm for a general haplotype solution on tree pedigrees with no recombination and its extensions.Journal of bioinformatics and computational biology · 2009Article
- Efficient haplotype inference from pedigrees with missing data using linear systems with disjoint-set data structures.Computational systems bioinformatics. Computational Systems Bioinformatics Conference · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Two grand challenges in the postgenomic era are to develop a detailed understanding of heritable variation in the human genome, and to develop robust strategies for identifying the genetic contribution to diseases and drug responses. Haplotypes of single nucleotide polymorphisms (SNPs) have been suggested as an effective representation of human variation, and various haplotype-based association mapping methods for complex traits have been proposed in the literature. However, humans are diploid and, in practice, genotype data instead of haplotype data are collected directly. Therefore, efficient and accurate computational methods for haplotype reconstruction are needed and have recently been investigated intensively, especially for tightly linked markers such as SNPs. This paper reviews statistical and combinatorial haplotyping algorithms using pedigree data, unrelated individuals, or pooled samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.