ArticlePediatric nephrology (Berlin, Germany)2008
High serological response to pneumococcal vaccine in nephrotic children at disease onset on high-dose prednisone.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The Italian Society for Pediatric Nephrology (SINePe) consensus document on the management of nephrotic syndrome in children: Part I - Diagnosis and treatment of the first episode and the first relapse.Italian journal of pediatrics · 2017Pooled it
- Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: general therapy.Clinical and experimental nephrology · 2015Guideline
- Interventions for preventing infection in nephrotic syndrome.The Cochrane database of systematic reviews · 2012Pooled it
- Dexamethasone treatment has no effect on the formation of pneumococcal antibodies during community-acquired pneumonia.Clinical and vaccine immunology : CVI · 2012Trial
- Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Vaccines and nephrotic syndrome: efficacy and safety.Pediatric nephrology (Berlin, Germany) · 2023Review
- Seroprotection against measles in previously vaccinated children with difficult-to-treat nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2022Article
- Vaccinations in Patients Receiving Systemic Drugs for Skin Disorders: What Can We Learn for SARS-Cov-2 Vaccination Strategies?Drugs in R&D · 2021Review
- An evidence-based guide to SARS-CoV-2 vaccination of patients on immunotherapies in dermatology.Journal of the American Academy of Dermatology · 2021Review
- Pediatric Immunization Practices in Nephrotic Syndrome: An Assessment of Provider and Parental Knowledge.Frontiers in pediatrics · 2020Article
- Influenza vaccination among children with idiopathic nephrotic syndrome: an investigation of practices.BMC nephrology · 2019Article
- Safety and Efficacy of Pneumococcal Vaccination in Pediatric Nephrotic Syndrome.Frontiers in pediatrics · 2019Review
- The non-immunosuppressive management of childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2016Review
- Vaccinations in children on immunosuppressive medications for renal disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- The ABC of pneumococcal infections and vaccination in patients with chronic kidney disease.Clinical kidney journal · 2015Article
- The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications.Pediatric nephrology (Berlin, Germany) · 2014Review
- Do vitamin D plasma levels impact vaccine response in children with idiopathic nephrotic syndrome?Pediatric nephrology (Berlin, Germany) · 2012Article
- Chapter 3: Steroid-sensitive nephrotic syndrome in children.Kidney international supplements · 2012Article
- [Infectious complications of biologic therapy in patients with rheumatoid arthritis].Zeitschrift fur Rheumatologie · 2010Review
- Polysaccharide pneumococcal vaccination of nephrotic children at disease onset-long-term data.Pediatric nephrology (Berlin, Germany) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our objective was to demonstrate that nephrotic children at disease onset and under high-dose prednisone respond to vaccination with 23-valent pneumococcal vaccine (PV). We compared the serological response after PV in 30 children with nephrotic syndrome, directly after initiation of prednisone therapy (60 mg/m2 body surface area) at disease onset (group 1), with the response in 13 patients who received the vaccine while in remission (group 2). Safety was studied, comparing disease course in group 1 with those in patients who did not receive any PV (group 3). In group 1, 23-valent PV antibody (Ab) levels increased tenfold after 1 month and remained increased after 1 year (P < 0.01). Ab response in the short term and in the long term was not different from that of patients in group 2. Serum albumin, age, or immunosuppressive drugs did not influence Ab response. Disease courses in groups 1 and 3 were not different. In conclusion, nephrotic children on high-dose glucocorticoid therapy respond to a 23-valent anti-PV. Children with steroid dependent/resistant forms acquire high Ab levels, even if early relapses delay the tapering of steroids or if immunosuppressive agents are introduced. Patients who relapse during the tapering of steroids already have increased anti-pneumococcal Ab at the time of relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.