ArticlePsychopharmacology2008
Anxiolytic-like effects of morphine and buprenorphine in the rat model of fear-potentiated startle: tolerance, cross-tolerance, and blockade by naloxone.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pharmacological modulation of conditioned fear in the fear-potentiated startle test: a systematic review and meta-analysis of animal studies.Psychopharmacology · 2023Pooled it
- Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects.PloS one · 2024Article
- Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use.Addiction neuroscience · 2023Article
- Intraperitoneal injection of buprenorphine on anxiety-like behavior and alteration in expression ofVeterinary research forum : an international quarterly journal · 2022Article
- A Possible Anti-anxiety Effect of Appetitive Aggression and a Possible Link to the Work of Donald Winnicott.Scandinavian journal of child and adolescent psychiatry and psychology · 2022Article
- Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Effects of morphine on place conditioning and ERKPsychopharmacology · 2018Article
- Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats.The international journal of neuropsychopharmacology · 2017Article
- Substance use modulates stress reactivity: Behavioral and physiological outcomes.Physiology & behavior · 2016Review
- The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and μ partial agonist, in mice.Psychopharmacology · 2016Article
- The long-term impact of early life pain on adult responses to anxiety and stress: Historical perspectives and empirical evidence.Experimental neurology · 2016Review
- Contrast-enhanced ultrasound of both kidneys in healthy, non-anaesthetized cats.Acta veterinaria Scandinavica · 2015Article
- Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice.Psychopharmacology · 2015Article
- Morphine administration during low ovarian hormone stage results in transient over expression of fear memories in females.Frontiers in behavioral neuroscience · 2015Article
- Attenuated effects of experimenter-administered heroin in adolescent vs. adult male rats: physical withdrawal and locomotor sensitization.Psychopharmacology · 2013Article
- Evaluation of anxiolytic activity of compound Valeriana jatamansi Jones in mice.BMC complementary and alternative medicine · 2012Article
- A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.Science translational medicine · 2012Article
- The effects of acute and chronic steady state methadone on memory retrieval in rats.Psychopharmacology · 2012Article
- Protracted manifestations of acute dependence after a single morphine exposure.Psychopharmacology · 2012Article
- Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.Journal of biomedical science · 2010Article
Corrections and comments
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2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleMorphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not.
objectivesEffects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pretreatment were assessed. Effects of chronic morphine and buprenorphine on tolerance, cross-tolerance, and withdrawal were also examined. MATERIALS AND
methodsFear-conditioned rats were given subcutaneous drug treatment immediately before testing for FPS. Experiment 1, rats were administered morphine (0.03, 0.25, 0.63, 2.5, or 10 mg/kg) or buprenorphine (0.004, 0.0075, 0.015, 0.03, or 0.25 mg/kg). Experiment 2, rats were given saline or naloxone (0.5 mg/kg) and 5 min later given saline, morphine (2.5 mg/kg), or buprenorphine (0.03 mg/kg). Experiment 3, rats received once-daily injections of saline, morphine (10 mg/kg), or buprenorphine (0.25 mg/kg) for 7 days. Immediately before testing, saline-treated rats were given saline, morphine (2.5 mg/kg), or buprenorphine (0.03 mg/kg), morphine-treated rats were given morphine (2.5 mg/kg) or buprenorphine (0.03 mg/kg), and buprenorphine-treated rats were given buprenorphine (0.03 mg/kg) or morphine (2.5 mg/kg). Tolerance and cross-tolerance in analgesia were assessed via the tail-flick test, as were naloxone-precipitated withdrawal.
resultsMorphine and buprenorphine had parallel dose-response curves in blocking FPS, with buprenorphine 40 times more potent than morphine. Naloxone reversed these effects. Morphine and buprenorphine showed tolerance and cross-tolerance in their anxiolytic-like and analgesic effects. Chronic buprenorphine produced less withdrawal than chronic morphine.
conclusionsCross-tolerance between morphine and buprenorphine suggests a common receptor mediating their anxiolytic-like and analgesic effects.
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