Evidence map›Paper›PMID 18323809›Full record

ArticleNature protocols2008

A protocol for a lung neovascularization model in rodents.

Rosemary C Jones, Diane Capen, Bodil Petersen, Rakesh K Jain, Dan G Duda

Abstract read
In one paragraph

Article in Nature protocols, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rosemary C JonesDepartment of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA. rcjones@partners.org
Diane Capen
Bodil Petersen
Rakesh K Jain
Dan G Duda

Funding

Vascular Normalization: Rolse of Perivascular CellsP01CA080124 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2000 to 2016
$35.0M
Role of BMDCs in Solid Tumor Growth and RelapseR01CA115767 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2006 to 2010
$2.2M
Murine Circulating Endothelial Precursors (CEPs) and Lung Capillary RepairR01HL089252 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JONES, ROSEMARY CRISTIAN · 2008 to 2012
$2.2M
Fi02 and Blood Vessel Formation in Adult LungR01HL070866 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JONES, ROSEMARY CRISTIAN · 2003 to 2006
$1.5M
NCI NIH HHS P01 CA080124NCI NIH HHS R01 CA115767NCI NIH HHS R01CA115767NHLBI NIH HHS R01 HL070866NHLBI NIH HHS R01HL 070866NHLBI NIH HHS R01 HL089252
6 · The paper itself

Abstract

By providing insight into the cellular events of vascular injury and repair, experimental model systems seek to promote timely therapeutic strategies for human disease. The goal of many current studies of neovascularization is to identify cells critical to the process and their role in vascular channel assembly. We propose here a protocol to analyze, in an in vivo rodent model, vessel and capillary remodeling (reorganization and growth) in the injured lung. Sequential analyses of stages in the assembly of vascular structures, and of relevant cell types, provide further opportunities to study the molecular and cellular determinants of lung neovascularization.

Indexed as

AnimalsBiomedical ResearchHyperoxiaLungLung InjuryMaleMiceModels, AnimalNeovascularization, PhysiologicNitrogenOxygenRatsNitrogenOxygen

Identifiers

PMID18323809
PMCPMC2676330

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.