ArticleThe EMBO journal2008
Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses.The Plant journal : for cell and molecular biology · 2017Article
- Endoplasmic reticulum-mediated signalling in cellular microdomains.Acta physiologica (Oxford, England) · 2017Review
- Golgi enzymes do not cycle through the endoplasmic reticulum during protein secretion or mitosis.Molecular biology of the cell · 2017Article
- Mitotic Golgi disassembly is required for bipolar spindle formation and mitotic progression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi.Journal of lipid research · 2016Article
- PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.The EMBO journal · 2016Article
- PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.Diabetes · 2013Article
- Modular organization of the mammalian Golgi apparatus.Current opinion in cell biology · 2012Review
- A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.Cell · 2011Article
- Golgi biogenesis.Cold Spring Harbor perspectives in biology · 2011Review
- Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics.PloS one · 2011Article
- Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis.Journal of cell science · 2010Article
- A major fraction of glycosphingolipids in model and cellular cholesterol-containing membranes is undetectable by their binding proteins.The Journal of biological chemistry · 2010Article
- Unraveling the Golgi ribbon.Traffic (Copenhagen, Denmark) · 2010Review
- Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets.Journal of cell science · 2009Article
- Spindle-dependent partitioning of the Golgi ribbon.Communicative & integrative biology · 2009Article
- Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis.Molecular microbiology · 2009Article
- The mitotic spindle mediates inheritance of the Golgi ribbon structure.The Journal of cell biology · 2009Article
- Induction of asymmetrical cell division to analyze spindle-dependent organelle partitioning using correlative microscopy techniques.Nature protocols · 2009Article
- Remodeling of the Golgi structure by ERK signaling.Communicative & integrative biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that reside as inactive precursors in the endoplasmic reticulum (ER) membrane. After sterol depletion, the proteins are transported to the Golgi apparatus, where they are cleaved by site-1 protease (S1P). Cleavage releases the active transcription factors, which then enter the nucleus to induce genes that regulate cellular levels of cholesterol and phospholipids. This regulation depends on the spatial separation of the Golgi and the ER, as mixing of the compartments induces unregulated activation of SREBPs. Here, we show that S1P is localized to the Golgi, but cycles continuously through the ER and becomes trapped when ER exit is inhibited. During mitosis, S1P is associated with mitotic Golgi clusters, which remain distinct from the ER. In mitotic cells, S1P is active, but SREBP is not cleaved as S1P and SREBP reside in different compartments. Together, these results indicate that the spatial separation of the Golgi and the ER is maintained during mitosis, which is essential to protect the S1P substrate SREBP from unregulated activation during mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.