ArticleLearning & memory (Cold Spring Harbor, N.Y.)2008
Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 104 citations in OpenAlex.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice.Cell · 2025Article
- A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8Brain research · 2024Article
- Choosing memory retrieval strategies: A critical role for inhibition in the dentate gyrus.Neurobiology of stress · 2022Article
- Review
- Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons.Neuron · 2022Article
- Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits.Neurobiology of stress · 2021Article
- Juvenile stress facilitates safety learning in male and female high alcohol preferring mice.Behavioural brain research · 2021Article
- Insights: fear of GAD.FEBS open bio · 2021Article
- Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.FEBS open bio · 2021Article
- Know safety, no fear.Neuroscience and biobehavioral reviews · 2020Review
- Animal models of PTSD: a challenge to be met.Molecular psychiatry · 2019Review
- Hippocampal network oscillations at the interplay between innate anxiety and learned fear.Psychopharmacology · 2019Review
- Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance.Brain structure & function · 2018Article
- Cued fear memory generalization increases over time.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Generalization of Conditioned Auditory Fear is Regulated by Maternal Effects on Ventral Hippocampal Synaptic Plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The Neurobiology of Fear Generalization.Frontiers in behavioral neuroscience · 2018Review
- Article
- The L-type voltage-gated calcium channel CaLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that plasticity of the amygdalar and hippocampal GABAergic system is critical for fear memory formation. In this study we investigated in wild-type and genetically manipulated mice the role of the activity-dependent 65-kDa isozyme of glutamic acid decarboxylase (GAD65) in the consolidation and generalization of conditioned fear. First, we demonstrate a transient reduction of GAD65 gene expression in the dorsal hippocampus (6 h post training) and in the basolateral complex of the amygdala (24 h post training) during distinct phases of fear memory consolidation. Second, we show that targeted ablation of the GAD65 gene in Gad65(-/-) mice results in a pronounced context-independent, intramodal generalization of auditory fear memory during long-term (24 h or 14 d) but not short-term (30 min) memory retrieval. The temporal specificity of both gene regulation and memory deficits in Gad65 mutant mice suggests that GAD65-mediated GABA synthesis is critical for the consolidation of stimulus-specific fear memory. This function appears to involve a modulation of neural activity patterns in the amygdalo-hippocampal pathway as indicated by a reduction in theta frequency synchronization between the amygdala and hippocampus of Gad65(-/-) mice during the expression of generalized fear memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.