ArticleStroke2008
Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study.
Article in Stroke, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Mortality and causes of death in the Familial Intracranial Aneurysm study.International journal of stroke : official journal of the International Stroke Society · 2013Trial
- Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease.Journal of nephrology · 2024Article
- Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.Neuromolecular medicine · 2019Review
- Article
- Observational
- Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis.Translational stroke research · 2018Article
- A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling.Journal of genetic counseling · 2017Review
- Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.Frontiers in public health · 2017Review
- MicroRNA and gene expression changes in unruptured human cerebral aneurysms.Journal of neurosurgery · 2016Article
- Molecular basis and genetic predisposition to intracranial aneurysm.Annals of medicine · 2014Review
- Zebrafish models of cerebrovascular disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.Stroke · 2012Article
- A genome-wide study of moyamoya-type cerebrovascular disease in the korean population.Journal of Korean Neurosurgical Society · 2011Article
- Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms.American journal of medical genetics. Part A · 2011Article
- The development and the use of experimental animal models to study the underlying mechanisms of CA formation.Journal of biomedicine & biotechnology · 2011Review
- Article
- Genome screen in familial intracranial aneurysm.BMC medical genetics · 2009Article
- Genome screen to detect linkage to common susceptibility genes for intracranial and aortic aneurysms.Stroke · 2009Article
- Susceptibility loci for intracranial aneurysm in European and Japanese populations.Nature genetics · 2008Article
- Genetic factors involves in intracranial aneurysms--actualities.Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
background and purposeEvidence supports a substantial genetic contribution to the risk of intracranial aneurysm (IA). The purpose of this study was to identify chromosomal regions likely to harbor genes that contribute to the risk of IA.
methodsMultiplex families having at least 2 individuals with "definite" or "probable" IA were ascertained through an international consortium. First-degree relatives of individuals with IA who were at increased risk of an IA because of a history of hypertension or present smoking were offered cerebral magnetic resonance angiography. A genome screen was completed using the Illumina 6K SNP system, and the resulting data from 192 families, containing 1155 genotyped individuals, were analyzed. Narrow and broad disease definitions were used when testing for linkage using multipoint model-independent methods. Ordered subset analysis was performed to test for a gene x smoking (pack-years) interaction.
resultsThe greatest evidence of linkage was found on chromosomes 4 (LOD=2.5; 156 cM), 7 (LOD=1.7; 183 cM), 8 (LOD=1.9; 70 cM), and 12 (LOD=1.6; 102 cM) using the broad disease definition. Using the average pack-years for the affected individuals in each family, the genes on chromosomes 4 (LOD=3.5; P=0.03), 7 (LOD=4.1; P=0.01) and 12 (LOD=3.6; P=0.02) all appear to be modulated by the degree of smoking in the affected members of the family. On chromosome 8, inclusion of smoking as a covariate did not significantly strengthen the linkage evidence, suggesting no interaction between the loci in this region and smoking.
conclusionsWe have detected possible evidence of linkage to 4 chromosomal regions. There is potential evidence for a gene x smoking interaction with 3 of the loci.
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