ArticleBlood2008
Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Hydrogen sulphide modifies the therapeutic potential of bone marrow mesenchymal stem cells in an adjuvant-induced polyarthritis rat model through the mitigation of angiogenesis, ectopic lymphoid tissue formation, and osteoclastogenesis.Inflammopharmacology · 2026Article
- The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells.Seminars in immunopathology · 2025Review
- Review
- Integrative Single-Cell Transcriptomic Analysis of Human Fetal Thymocyte Development.Frontiers in genetics · 2021Article
- Enhanced Susceptibility of Galectin-1 Deficient Mice to Experimental Colitis.Frontiers in immunology · 2021Article
- The Emerging Role of Galectins andCells · 2020Review
- Thymic Microenvironment Is Modified by Malnutrition andFrontiers in cellular and infection microbiology · 2019Article
- Engineering galectin-glycan interactions for immunotherapy and immunomodulation.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Galectin-1 regulates tissue exit of specific dendritic cell populations.The Journal of biological chemistry · 2015Article
- Evolving mechanistic insights into galectin functions.Methods in molecular biology (Clifton, N.J.) · 2015Review
- Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology.Frontiers in pediatrics · 2015Review
- Adaptive immune activation: glycosylation does matter.Nature chemical biology · 2013Article
- Galectins in the Pathogenesis of Rheumatoid Arthritis.Journal of clinical & cellular immunology · 2013Article
- Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response.PloS one · 2012Article
- When galectins recognize glycans: from biochemistry to physiology and back again.Biochemistry · 2011Review
- Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis.Cancer research · 2011Article
- The road less traveled: regulation of leukocyte migration across vascular and lymphatic endothelium by galectins.Journal of clinical immunology · 2011Review
- Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.The Journal of infectious diseases · 2010Article
- N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death.The Journal of biological chemistry · 2010Article
- CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
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10 authors.
Funding
Abstract
During thymocyte development, the T-cell receptor (TCR) can discriminate major histocompatibility complex (MHC)/peptide ligands over a narrow range of affinities and translate subtle differences into functional fate decisions. How small differences in TCR input are translated into absolute differences in functional output is unclear. We examined the effects of galectin-1 ablation in the context of class-I-restricted thymocyte development. Galectin-1 expression opposed TCR partial agonist-driven positive selection, but promoted TCR agonist-driven negative selection of conventional CD8(+) T cells. Galectin-1 expression also promoted TCR agonist-driven CD8alphaalpha intestinal intraepithelial lymphocytes (IEL) development. Recombinant galectin-1 enhanced TCR binding to agonist/MHC complexes and promoted a negative-selection-signaling signature, reflected in intensified rapid and transient extracellular signal-regulated kinase (ERK) activation. In contrast, galectin-1 expression antagonized ERK activity in thymocytes undergoing positive selection. We propose that galectin-1 aids in discriminating TCR-directed fate decisions by promoting TCR binding to agonist/MHC complexes and enforcing agonist-driven signals, while opposing partial-agonist signals. In this way, galectin-1 widens the distinction between TCR-directed functional fate cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.