ArticleEndocrine2007
Expression of Id1 in adult, regenerating and developing pancreas.
Article in Endocrine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues.Science (New York, N.Y.) · 2025Article
- Engineering islets from stem cells for advanced therapies of diabetes.Nature reviews. Drug discovery · 2021Review
- Recent developments in β-cell differentiation of pluripotent stem cells induced by small and large molecules.International journal of molecular sciences · 2014Review
- A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Genetics · 2012Article
- ID'ing a novel inhibitor of β-cell function, Id1.Diabetes · 2011Article
- Article
- Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic beta-cells in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several key transcription factors are necessary for alpha cell development in the pancreas. In this study, we describe the expression of Inhibition of DNA-binding protein 1 (Id1) in the developing as well as the normal adult pancreas. We found co-expression of Id1 with bone morphogenetic protein (BMP) receptor in alpha cells. Inhibition of BMP4 signaling with a specific neutralizing antibody slightly decreases the proportion of glucagon cells in the adult pancreas but had a significant effect in a model of pancreas regeneration. In late embryonic pancreas, Id1 co-localized with GATA4, a transcription factor known for its critical function in glucagon cell development. However, in early postnatal period, the expression of Id1 and GATA4 diverged with Id1 identified in glucagon cells and GATA4 restricted to the acinar pancreas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.