ArticleNeuro-degenerative diseases2008
Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease.
Article in Neuro-degenerative diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease.Acta neuropathologica communications · 2025Article
- Expression profiling of precuneus layer III cathepsin D-immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability.The Journal of comparative neurology · 2020Article
- Fronto-temporal galanin modulates impulse control.Psychopharmacology · 2020Article
- Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis.Annals of neurology · 2018Article
- Unraveling the genes implicated in Alzheimer's disease.Biomedical reports · 2017Article
- Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.Brain structure & function · 2017Article
- Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease.Acta neuropathologica communications · 2017Article
- Anticholinergic Drug Use and Risk to Cognitive Performance in Older Adults with Questionable Cognitive Impairment: A Cross-Sectional Analysis.Drugs & aging · 2016Article
- Hippocampal plasticity during the progression of Alzheimer's disease.Neuroscience · 2015Review
- Review
- Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.Veterinary research · 2013Article
- Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases.Current genomics · 2012Article
- Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2012Article
- Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Journal of chemical neuroanatomy · 2011Article
- Gene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals.PloS one · 2011Article
- Biological impact of low dose-rate simulated solar particle event radiation in vivo.Radiation and environmental biophysics · 2010Article
- Genome-wide association studies in Alzheimer's disease.Human molecular genetics · 2009Review
- Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFibers containing galanin (GAL) enlarge and hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons in late-stage Alzheimer's disease (AD), yet the physiological consequences of this phenomenon are unclear.
objectiveTo determine whether GAL hyperinnervation of cholinergic NB neurons modulates the expression of genes critical to cholinergic transmission [e.g. acetylcholine (ACh) metabolism and ACh receptors] in AD.
methodsSingle-cell gene expression profiling was used to compare cholinergic mRNA levels in non-GAL-hyperinnervated NB neurons in tissue autopsied from cases classified as having no cognitive impairment (NCI) or late-stage AD (AD/GAL-) and in GAL-hyperinnervated (AD/GAL+) NB neurons from the same AD subjects.
resultsAD/GAL+ cells displayed a significant upregulation in choline acetyltransferase (ChAT) mRNA expression compared to NCI and AD/GAL- cells.
conclusionGAL fiber hyperinnervation of cholinergic NB neurons upregulates the expression of ChAT, the synthetic enzyme for ACh, suggesting that GAL regulates the cholinergic tone of CBF neurons in AD.
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Registered trials
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