ArticleJournal of immunology (Baltimore, Md. : 1950)2008
A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Early expression of mature αβ TCR in CD4Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- T-cell receptor affinity in the age of cancer immunotherapy.Molecular carcinogenesis · 2020Review
- Identification of key miRNA‑mRNA pairs in septic mice by bioinformatics analysis.Molecular medicine reports · 2019Article
- Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.Science advances · 2015Article
- Detection of constant domain of human T cell antigen receptor alpha-chain via novel monoclonal antibody 7F18.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2014Article
- Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.Nature communications · 2014Article
- IgG Fab fragments forming bivalent complexes by a conformational mechanism that is reversible by osmolytes.The Journal of biological chemistry · 2012Article
- The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- IP-FCM measures physiologic protein-protein interactions modulated by signal transduction and small-molecule drug inhibition.PloS one · 2012Article
- Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.The Journal of experimental medicine · 2010Article
- The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.Nature reviews. Immunology · 2009Review
- T cell activation.Annual review of immunology · 2009Review
- Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
TCR engagement by peptide-MHC class I (pMHC) ligands induces a conformational change (Deltac) in CD3 (CD3Deltac) that contributes to T cell signaling. We found that when this interaction took place between primary T lineage cells and APCs, the CD8 coreceptor was required to generate CD3Deltac. Interestingly, neither enhancement of Ag binding strength nor Src kinase signaling explained this coreceptor activity. Furthermore, Ag-induced CD3Deltac was developmentally attenuated by the increase in sialylation that accompanies T cell maturation and limits CD8 activity. Thus, both weak and strong ligands induced CD3Deltac in preselection thymocytes, but only strong ligands were effective in mature T cells. We propose that CD8 participation in the TCR/pMHC interaction can physically regulate CD3Deltac induction by "translating" productive Ag encounter from the TCR to the CD3 complex. This suggests one mechanism by which the developmentally regulated variation in CD8 sialylation may contribute to the developmental tuning of T cell sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.