ArticleAmerican journal of physiology. Cell physiology2008
Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release.
Article in American journal of physiology. Cell physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.Communications biology · 2023Article
- Loss of S100A1 expression leads to CaPhysiological reports · 2018Article
- Specific association of growth-associated protein 43 with calcium release units in skeletal muscles of lower vertebrates.European journal of histochemistry : EJH · 2014Article
- Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells.FEBS letters · 2014Article
- Real-time imaging of NADPH oxidase activity in living cells using a novel fluorescent protein reporter.PloS one · 2013Article
- S100A1 and calmodulin regulation of ryanodine receptor in striated muscle.Cell calcium · 2011Review
- Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.American journal of physiology. Cell physiology · 2011Article
- Transcriptional profiling identifies differentially expressed genes in developing turkey skeletal muscle.BMC genomics · 2011Article
- S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle.American journal of physiology. Cell physiology · 2010Article
- Mitochondrial redox potential during contraction in single intact muscle fibers.Muscle & nerve · 2010Article
- S100A1 and calmodulin compete for the same binding site on ryanodine receptor.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Calmodulin is a ubiquitous Ca2+ binding protein that binds to ryanodine rectors (RyR) and is thought to modulate its activity. Here we evaluated the effects of recombinant calmodulin on the rate of occurrence and spatial properties of Ca2+ sparks as an assay of activation in saponin-permeabilized mouse myofibers. Control myofibers exhibited a time-dependent increase and subsequent decrease in spark frequency. Recombinant wild-type calmodulin prevented the time-dependent appearance of Ca2+ sparks and decreased the derived Ca2+ flux from the sarcoplasmic reticulum during a spark by approximately 37%. A recombinant Ca2+-insensitive form of calmodulin resulted in an instantaneous increase in spark frequency as well as an increase in the derived Ca2+ flux by approximately 24%. Endogenous calmodulin was found to primarily localize to the Z-line. Surprisingly, removal of endogenous calmodulin did not alter the time dependence of Ca2+ spark appearance. These results indicate that calmodulin may not be essential for RyR1-dependent Ca2+ release in adult mammalian skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.