ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Common themes in evoked ion channel translocation in neuroplastic and homeostatic plasticity.Frontiers in pharmacology · 2026Review
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Molecular psychiatry · 2026Article
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Research square · 2025Article
- Cholinergic depolarization recruits a persistent CaJournal of neurophysiology · 2023Article
- Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in mice.Frontiers in genetics · 2022Article
- Intracellular G-actin targeting of peripheral sensory neurons by the multifunctional engineered protein C2C confers relief from inflammatory pain.Scientific reports · 2020Article
- Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.Molecular brain · 2019Article
- Protein Kinase C Enhances Electrical Synaptic Transmission by Acting on Junctional and Postsynaptic CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Diacylglycerol-mediated regulation of Aplysia bag cell neuron excitability requires protein kinase C.The Journal of physiology · 2016Article
- Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.Scientific reports · 2016Article
- EXPRESS: F-actin links Epac-PKC signaling to purinergic P2X3 receptors sensitization in dorsal root ganglia following inflammation.Molecular pain · 2016Article
- PKC enhances the capacity for secretion by rapidly recruiting covert voltage-gated Ca2+ channels to the membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states.Molecular pain · 2012Article
- The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release.Frontiers in physiology · 2012Article
- The involvement of voltage-operated calcium channels in somato-dendritic oxytocin release.PloS one · 2011Article
- The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells.American journal of physiology. Cell physiology · 2010Article
- Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.The Journal of comparative neurology · 2010Article
- Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons.Journal of cell science · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Activation of protein kinase C (PKC) potentiates secretion in Aplysia peptidergic neurons, in part by inducing new sites for peptide release at growth cone terminals. The mechanisms by which ion channels are trafficked to such sites are, however, not well understood. We now show that PKC activation rapidly recruits new Ca(V)2 subunits to the plasma membrane, and that recruitment is blocked by latrunculin B, an inhibitor of actin polymerization. In contrast, inhibition of microtubule polymerization selectively prevents the appearance of Ca(V)2 subunits only at the distal edge of the growth cone. In resting neurons, Ca(V)2-containing organelles reside in the central region of growth cones, but are absent from distal lamellipodia. After activation of PKC, these organelles are transported on microtubules to the lamellipodium. The ability to traffic to the most distal sites of channel insertion inside the lamellipodium does, therefore, not require intact actin but requires intact microtubules. Only after activation of PKC do Ca(V)2 channels associate with actin and undergo insertion into the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.