ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Generation of eupnea and sighs by a spatiochemically organized inspiratory network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 90 citations in OpenAlex.
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the PreBötzinger Complex of the Ventrolateral Medulla.Molecular neurobiology · 2026Article
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the preBötzinger Complex of the Ventrolateral Medulla.Research square · 2026Article
- Plasticity induced loss of apnea alarm through repeated apneas: A proposed mechanism for respiratory sudden death.Epilepsy & behavior : E&B · 2025Review
- Roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, induces respiratory frequency plasticity that is resistant to inflammation in neonatal rat in vitro preparations.Respiratory physiology & neurobiology · 2025Article
- Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex.The Journal of physiology · 2024Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- The psychophysiology of the sigh: I: The sigh from the physiological perspective.Biological psychology · 2022Review
- Dynamic Rhythmogenic Network States Drive Differential Opioid Responses in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Calcium Imaging Analysis of Cellular Responses to Hypercapnia and Hypoxia in the NTS of Newborn Rat Brainstem Preparation.Frontiers in physiology · 2021Article
- Characterization and Classification of Electrophysiological Signals Represented as Visibility Graphs Using the Maxclique Graph.Frontiers in bioengineering and biotechnology · 2020Article
- Time and dose-dependent impairment of neonatal respiratory motor activity after systemic inflammation.Respiratory physiology & neurobiology · 2020Article
- A spatially dynamic network underlies the generation of inspiratory behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.PLoS biology · 2019Article
- Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a CaThe Journal of physiology · 2018Article
- Breathing matters.Nature reviews. Neuroscience · 2018Review
- The interdependence of excitation and inhibition for the control of dynamic breathing rhythms.Nature communications · 2018Article
- A genetically encoded CaBMC biology · 2018Article
- Fate mapping neurons and glia derived from Dbx1-expressing progenitors in mouse preBötzinger complex.Physiological reports · 2017Article
- Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.Pflugers Archiv : European journal of physiology · 2017Article
- The peptidergic control circuit for sighing.Nature · 2016Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of the rhythmogenic pre-Bötzinger complex (preBötC) inspiratory network, which remains active in a transverse brainstem slice, greatly increased the understanding of neural respiratory control. However, basic questions remain unanswered such as (1) What are the necessary and sufficient slice boundaries for a functional preBötC? (2) Is the minimal preBötC capable of reconfiguring between inspiratory-related patterns (e.g., fictive eupnea and sighs)? (3) How is preBötC activity affected by surrounding structures? Using newborn rat slices with systematically varied dimensions in physiological [K(+)] (3 mM), we found that a 175 microm thickness is sufficient for generating inspiratory-related rhythms. In 700-microm-thick slices with unilaterally exposed preBötC, a kernel <100 microm thick, centered 0.5 mm caudal to the facial nucleus, is necessary for rhythm generation. Slices containing this kernel plus caudal structures produced eupneic bursts of regular amplitude, whereas this kernel plus rostral tissue generated sighs, intermingled with eupneic bursts of variable amplitude ("eupnea-sigh pattern"). After spontaneous arrest of rhythm, substance-P or neurokinin-1 (NK1) receptor agonist induced the eupnea-sigh burst pattern in > or = 250-microm-thick slices, whereas thyrotropin-releasing hormone or phosphodiesterase-4 blockers evoked the eupnea burst pattern. Endogenous rhythm was depressed by NK1 receptor antagonism. Multineuronal Ca(2+) imaging revealed that preBötC neurons reconfigure between eupnea and eupnea-sigh burst patterns. We hypothesize a (gradient-like) spatiochemical organization of regions adjacent to the preBötC, such that a small preBötC inspiratory-related oscillator generates eupnea under the dominant influence of caudal structures or thyrotropin-releasing hormone-like transmitters but eupnea-sigh activity when the influence of rostral structures or substance-P-like transmitters predominates.
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