ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed, 161 citations in OpenAlex.
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Effects of Stress and Allopregnanolone on the Expression of Neurotrophins and TrkB Receptor in the Sheep Hippocampus.International journal of molecular sciences · 2025Article
- Sensory Stimulation-dependent Npas4 Expression in the Olfactory Bulb during Early Postnatal Development.Experimental neurobiology · 2024Article
- Single-cell transcriptomic analysis reveals the adverse effects of cadmium on the trajectory of neuronal maturation.Cell biology and toxicology · 2023Article
- Article
- Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury.CNS neuroscience & therapeutics · 2023Article
- Differential contribution of TrkB and p75Frontiers in molecular neuroscience · 2023Article
- Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.Scientific reports · 2022Article
- Distinct Effects of BDNF and NT-3 on the Dendrites and Presynaptic Boutons of Developing Olfactory Bulb GABAergic Interneurons In Vitro.Cellular and molecular neurobiology · 2022Article
- Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor.Frontiers in molecular neuroscience · 2022Article
- Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20.Stem cell research & therapy · 2021Article
- Relationship between depression and olfactory sensory function: a review.Chemical senses · 2021Review
- Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis.Advances in experimental medicine and biology · 2021Review
- Inducible and conditional activation of ERK5 MAP kinase rescues mice from cadmium-induced olfactory memory deficits.Neurotoxicology · 2020Article
- Young adult-born neurons improve odor coding by mitral cells.Nature communications · 2020Article
- Genetic Increases in Olfactory Bulb BDNF Do Not Enhance Survival of Adult-Born Granule Cells.Chemical senses · 2020Article
- Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis.iScience · 2019Article
- An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants.The EMBO journal · 2019Article
- Early Life Stress Delays Sexual Maturation in Female Mice.Frontiers in molecular neuroscience · 2019Article
- CPEB4-Dependent Neonate-Born Granule Cells Are Required for Olfactory Discrimination.Frontiers in behavioral neuroscience · 2019Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Neurogenesis, the division, migration, and differentiation of new neurons, occurs throughout life. Brain derived neurotrophic factor (BDNF) has been identified as a potential signaling molecule regulating neurogenesis in the subventricular zone (SVZ), but its functional consequences in vivo have not been well defined. We report marked and unexpected deficits in survival but not proliferation of newly born cells of adult knock-in mice containing a variant form of BDNF [a valine (Val) to methionine (Met) substitution at position 66 in the prodomain of BDNF (Val66Met)], a genetic mutation shown to lead to a selective impairment in activity-dependent BDNF secretion. Utilizing knock-out mouse lines, we identified BDNF and tyrosine receptor kinase B (TrkB) as the critical molecules for the observed impairments in neurogenesis, with p75 knock-out mice showing no effect on cell proliferation or survival. We then localized the activated form of TrkB to a discrete population of cells, type A migrating neuroblasts, and demonstrate a decrease in TrkB phosphorylation in the SVZ of Val66Met mutant mice. With these findings, we identify TrkB signaling, potentially through activity dependent release of BDNF, as a critical step in the survival of migrating neuroblasts. Utilizing a behavioral task shown to be sensitive to disruptions in olfactory bulb neurogenesis, we identified specific impairments in spontaneous olfactory discrimination, but not general olfactory sensitivity or habituation to olfactory stimuli in BDNF mutant mice. Through these observations, we have identified novel links between genetic variant BDNF and adult neurogenesis in vivo, which may contribute to significant impairments in olfactory function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.