ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Optogenetic and Endogenous Modulation of CaInternational journal of molecular sciences · 2025Review
- Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice.Pharmacology research & perspectives · 2022Article
- Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy.Marine drugs · 2021Article
- Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2.Frontiers in neuroscience · 2019Article
- (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.Molecular neurobiology · 2016Article
- Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons.Pflugers Archiv : European journal of physiology · 2015Article
- Article
- Differentiation defects in primary motoneurons from a SMARD1 mouse model that are insensitive to treatment with low dose PEGylated IGF1.Rare diseases (Austin, Tex.) · 2014Article
- Calcium signals and FGF-2 induced neurite growth in cultured parasympathetic neurons: spatial localization and mechanisms of activation.Pflugers Archiv : European journal of physiology · 2013Article
- Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth.Nature neuroscience · 2012Article
- Interleukin-17A increases neurite outgrowth from adult postganglionic sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Substrate three-dimensionality induces elemental morphological transformation of sensory neurons on a physiologic timescale.Tissue engineering. Part A · 2012Article
- Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction.Developmental neurobiology · 2011Review
- Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.Nature neuroscience · 2011Article
- Laminin-121--recombinant expression and interactions with integrins.Matrix biology : journal of the International Society for Matrix Biology · 2010Article
- Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The N-type voltage-gated calcium channel: when a neuron reads a map.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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5 authors at 3 institutions in 1 country.
Funding
Abstract
Axons and dendrites of developing neurons establish distributed innervation patterns enabling precise discrimination in sensory systems. We describe the role of the extracellular matrix molecule, laminin beta2, interacting with the Ca(V)2.2 calcium channel in establishing appropriate sensory innervation. In vivo, Ca(V)2.2 is expressed on the growth cones of Xenopus laevis sensory neurites and laminin beta2 is expressed in the skin. Culturing neurons on a laminin beta2 substrate inhibits neurite outgrowth in a specific and calcium-dependent manner. Blocking signaling between laminin beta2 and Ca(V)2.2 leads to increased numbers of sensory terminals in vivo. These findings suggest that interactions between extracellular matrix molecules and calcium channels regulate connectivity in the developing nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.