ArticleClinical journal of the American Society of Nephrology : CJASN2008
Cardiovascular outcomes in the outpatient kidney transplant clinic: the Framingham risk score revisited.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02058875 (Comparisons Of Inflammatory Biomarkers And Cardiovascular Risk Scores Before And After Conversion To Full Dose Myfortic® Using Two Hour Neoral® Monitoring.), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparisons Of Inflammatory Biomarkers And Cardiovascular Risk Scores Before And After Conversion To Full Dose Myfortic® Using Two Hour Neoral® Monitoring.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Validity of cardiovascular risk prediction models in kidney transplant recipients.TheScientificWorldJournal · 2014Pooled it
- New kidneys, old risks: cardiovascular challenges after transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Framingham risk score is a useful indicator of posttransplant cardiovascular events and survival among Korean kidney transplant recipients: a nationwide, prospective cohort study.Kidney research and clinical practice · 2025Article
- Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Early cardiovascular events and cardiovascular death after renal transplantation: role of pretransplant risk factors.Clinical and experimental nephrology · 2021Observational
- Lifestyle, Inflammation, and Vascular Calcification in Kidney Transplant Recipients: Perspectives on Long-Term Outcomes.Journal of clinical medicine · 2020Article
- Comparison of different algorithms for the assessment of cardiovascular risk after kidney transplantation by the time of entering waiting list.Clinical kidney journal · 2020Article
- Induction immunosuppression agents as risk factors for incident cardiovascular events and mortality after kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Clinical Outcomes of ABO-Incompatible Kidney Transplantation in Patients with End-Stage Kidney Disease due to Diabetes Nephropathy.Urologia internationalis · 2019Observational
- Comparing the Predictive Power of Preoperative Risk Assessment Tools to Best Predict Major Adverse Cardiac Events in Kidney Transplant Patients.Surgery research and practice · 2019Article
- Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients.The Korean journal of internal medicine · 2018Article
- Interaction of Serum Phosphate with Age as Predictors of Cardiovascular Risk Scores in Stable Renal Transplant Recipients.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Article
- Cardiovascular disease: Risk factors and applicability of a risk model in a Greek cohort of renal transplant recipients.World journal of transplantation · 2017Article
- Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.Circulation research · 2015Article
- Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients.Transplantation · 2012Article
- Diabetes and kidney transplantation: past, present, and future.Current diabetes reports · 2012Review
- Incidence of cardiovascular events after kidney transplantation and cardiovascular risk scores: study protocol.BMC cardiovascular disorders · 2011Article
- Hyperlipidaemia in paediatric patients: the role of lipid-lowering therapy in clinical practice.Drug safety · 2010Review
- Review
- Cardiac evaluation prior to kidney transplantation.Seminars in dialysisArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCardiovascular disease is an important cause of morbidity and death in kidney transplant recipients. This study examines the Framingham risk score's ability to predict cardiac and stroke events. Because cyclosporine and tacrolimus have different cardiovascular risk profiles, these agents were also examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A prospective cohort evaluation of 540 patients were followed for a median of 4.7 yr in an outpatient kidney transplant clinic. Baseline Framingham risk scores were calculated and all cardiovascular outcomes were collected.
resultsRates per 100 patient-years were 1.79 for cardiac and 0.78 for stroke events. The ratio of observed-to-predicted cardiac events was 1.64-fold higher [95% confidence interval (CI) 1.19 to 2.94] for the cohort, 2.74-fold higher (95% CI 1.70 to 4.24) in patients age 45 to 60 with prior cardiac disease or diabetes mellitus, but not higher in other age subgroups. Stroke was not increased above predicted. Risk scores for cardiac (c = 0.65, P = 0.003) and stroke (c = 0.71, P = 0.004) events were modest predictors. 10-yr event scores for cardiac (9.3 versus 13.5%, P < 0.001) and stroke (7.1 versus 10.0%, P = 0.002) were lower for tacrolimus compared with cyclosporine-treated patients. However observed cardiac events were higher in tacrolimus recipients (2.50, 95% CI 1.09 to 5.90) in an adjusted Cox model.
conclusionsAlthough risk scores are only modest predictors, patients with the highest event rates are easily identified. Treating high-risk patients with cardioprotective medications should remain a priority.
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