ArticleProceedings of the National Academy of Sciences of the United States of America2008
Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Enhancers in T Cell development and malignant lesions.Cell death discovery · 2024Review
- A conserved element in the first intron ofFrontiers in immunology · 2024Article
- The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintainGenes & development · 2019Article
- Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.Scientific reports · 2017Article
- Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.Frontiers in immunology · 2017Review
- LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.Experimental hematology · 2014Article
- Transcriptional control of CD4 and CD8 coreceptor expression during T cell development.Cellular and molecular life sciences : CMLS · 2013Review
- Inducible mouse models illuminate parameters influencing epigenetic inheritance.Development (Cambridge, England) · 2013Article
- A general approach for controlling transcription and probing epigenetic mechanisms: application to the CD4 locus.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.Molecular cell · 2012Article
- Notch signalling inhibits CD4 expression during initiation and differentiation of human T cell lineage.PloS one · 2012Article
- The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.Current topics in microbiology and immunology · 2012Review
- Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.Seminars in immunology · 2011Review
- Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection.Seminars in immunology · 2010Review
- The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish.Blood · 2009Article
- Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.Molecular and cellular biology · 2009Article
- Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex.European journal of immunology · 2009Article
- Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
The CD4 gene is regulated in a stage-specific manner during T cell development, being repressed in CD4(-)CD8(-) double-negative (DN) and CD8 cells, but expressed in CD4(+)CD8(+) double-positive (DP) and CD4 cells. Furthermore, the expression/repression pattern is reversible in developing (DN and DP) thymocytes, but irreversible in mature (CD4 and CD8) T cells. Here, we explored the molecular mechanisms underlying this complex mode of regulation by examining the nucleoprotein structure of the CD4 locus throughout T cell development and in DN cells lacking the CD4 silencer. In DN cells, the CD4 enhancer is preloaded with multiple transcription activators, but p300 recruitment is impaired by the silencer that is associated with the repressor Runx1. DP cells achieve high-level CD4 expression via a combination of CD4 derepression and true activation, but Runx1 remains bound to the silencer that retains an open chromatin configuration. In CD4 cells, Runx1 dissociates from the silencer that has become less accessible, and CD4 transcription appears to be achieved via a mechanism distinct from that operating in DP cells. In CD8 cells, the CD4 promoter becomes incorporated into heterochromatin-like structure. Our data shed light on the molecular basis of CD4 regulation and provide a conceptual framework for understanding how the same regulatory elements can mediate both reversible and irreversible CD4 regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.