ReviewThe American journal of pathology2008
Liver repopulation and carcinogenesis: two sides of the same coin?
Review in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Cell competition in primary and metastatic colorectal cancer.Oncogenesis · 2024Review
- Gray zone of hepatitis B virus infection.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Hepatocellular Carcinoma and Hepatitis: Advanced Diagnosis and Management with a Focus on the Prevention of Hepatitis B-Related Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2023Review
- Hepatitis B Virus Treatment and Hepatocellular Carcinoma: Controversies and Approaches to Consensus.Liver cancer · 2022Review
- [Research progress on the characteristics of immune tolerant phase and antiviral therapy in children with chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Review
- Increasing on-treatment hepatocellular carcinoma risk with decreasing baseline viral load in HBeAg-positive chronic hepatitis B.The Journal of clinical investigation · 2022Article
- Aging and Cancer: The Waning of Community Bonds.Cells · 2021Review
- Secondary prevention of hepatitis B virus-related hepatocellular carcinoma with current antiviral therapies.The Kaohsiung journal of medical sciences · 2021Review
- Hepatitis B Virus DNA Integration and Clonal Expansion of Hepatocytes in the Chronically Infected Liver.Viruses · 2021Review
- Cell competition in liver carcinogenesis.World journal of hepatology · 2020Review
- Animal Modeling of Pediatric Liver Cancer.Cancers · 2020Review
- Regenerative Medicine: Shedding Light on the Link between Aging and Cancer.Cell transplantation · 2017Review
- Review
- Viral hepatitis: 'Immune tolerance' in HBV infection: danger lurks.Nature reviews. Gastroenterology & hepatology · 2016Article
- HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant.Gastroenterology · 2016Article
- Nucleos(t)ide analogs in the prevention of hepatitis B virus related hepatocellular carcinoma.World journal of hepatology · 2015Review
- Molecular biology of hepatitis B virus infection.Virology · 2015Review
- Animal models and the molecular biology of hepadnavirus infection.Cold Spring Harbor perspectives in medicine · 2015Review
- S-adenosylmethionine in liver health, injury, and cancer.Physiological reviews · 2012Review
- Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.International journal of molecular sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver repopulation by transplanted normal hepatocytes has been described in a number of experimental settings. Extensive repopulation can also occur from the selective proliferation of endogenous normal hepatocytes, both in experimental animals and in the human liver. This review highlights the intriguing association between clinical and experimental conditions related to liver repopulation and an increased risk for development of hepatocellular carcinoma. It is suggested that any microenvironment that is able to sustain the clonal growth of normal transplanted (or endogenous) hepatocytes is also geared to select for the emergence of rare resistant cells with an altered phenotype. Whereas the first pathway leads to liver repopulation with normal histology, the latter results in the growth of focal proliferative lesions and carries an increased risk of neoplastic disease. The implications of this association are discussed, both in terms of pathogenetic significance and possible therapeutic exploitation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.