ArticleThe American journal of pathology2008
Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Cellular heterogeneity of hepatic granuloma formation and evolution in murine schistosomiasis japonica.Nature communications · 2026Article
- Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung.Mucosal immunology · 2023Article
- A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia.Journal of clinical immunology · 2022Article
- Comprehensive Transcriptome Analysis of Patients With Keratoconus Highlights the Regulation of Immune Responses and Inflammatory Processes.Frontiers in genetics · 2022Article
- The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments.Nature communications · 2021Article
- Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration.Nature cancer · 2021Article
- Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.Respiratory research · 2021Review
- Innate Immune Response Against HIV-1.Advances in experimental medicine and biology · 2021Article
- Iron sequestration by transferrin 1 mediates nutritional immunity inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli.Journal of innate immunity · 2019Article
- Mouse Models and Tools for theFrontiers in immunology · 2019Review
- Innate Nutritional Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Iron and infection.International journal of hematology · 2018Review
- TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2015Article
- Lactoferrin-iCre: a new mouse line to study uterine epithelial gene function.Endocrinology · 2014Article
- Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells.Haematologica · 2014Article
- Article
- The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice.BMC genomics · 2013Article
- Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Identification of anti-inflammatory and other biological activities of 3-carboxamide, 3-carbohydrazide and ester derivatives of gatifloxacin.Chemistry Central journal · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactoferrin (LF) is an iron-binding protein found in milk, mucosal secretions, and the secondary granules of neutrophils in which it is considered to be an important factor in the innate immune response against microbial infections. Moreover, LF deficiency in the secondary granules of neutrophils has long been speculated to contribute directly to the hypersusceptibility of specific granule deficiency (SGD) patients to severe, life-threatening bacterial infections. However, the exact physiological significance of LF in neutrophil-mediated host defense mechanisms remains controversial and has not yet been clearly established in vivo using relevant animal models. In this study, we used lactoferrin knockout (LFKO) mice to directly address the selective role of LF in the host defense response of neutrophils and to determine its contribution, if any, to the phenotype of SGD. Neutrophil maturation, migration, phagocytosis, granule release, and antimicrobial response to bacterial challenge were unaffected in LFKO mice. Interestingly, a stimulus-dependent defect in the oxidative burst response of LFKO neutrophils was observed in that normal activation was seen in response to opsonized bacteria whereas an impaired response was evident after phorbol myristate-13-acetate stimulation. Taken together, these results indicate that although LF deficiency alone is not a primary cause of the defects associated with SGD, this protein does play an immunomodulatory role in the oxidative burst response of neutrophils.
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