ArticleJournal of virology2008
A novel methyltransferase methylates Cucumber mosaic virus 1a protein and promotes systemic spread.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cucumber Mosaic Virus 1a Protein Interacts with the Tobacco SHE1 Transcription Factor and Partitions between the Nucleus and the Tonoplast Membrane.The plant pathology journal · 2021Article
- The NIa-Protease Protein Encoded by theFrontiers in microbiology · 2020Article
- Epigenetics in the plant-virus interaction.Plant cell reports · 2019Review
- Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.PloS one · 2016Article
- Four sequence positions of the movement protein of Cucumber mosaic virus determine the virulence against cmv1-mediated resistance in melon.Molecular plant pathology · 2015Article
- Arabidopsis Pumilio protein APUM5 suppresses Cucumber mosaic virus infection via direct binding of viral RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Viral and cellular factors involved in Phloem transport of plant viruses.Frontiers in plant science · 2013Article
- Article
- Identification of tobacco proteins associated with the stem-loop 1 RNAs of Potato virus X.Molecules and cells · 2012Article
- Cucumber mosaic virus: viral genes as virulence determinants.Molecular plant pathology · 2012Review
- Helicase domain encoded by Cucumber mosaic virus RNA1 determines systemic infection of Cmr1 in pepper.PloS one · 2012Article
- Suppression of bamboo mosaic virus accumulation by a putative methyltransferase in Nicotiana benthamiana.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammalian and yeast systems, methyltransferases have been implicated in the regulation of diverse processes, such as protein-protein interactions, protein localization, signal transduction, RNA processing, and transcription. The Cucumber mosaic virus (CMV) 1a protein is essential not only for virus replication but also for movement. Using a yeast two-hybrid system with tobacco plants, we have identified a novel gene encoding a methyltransferase that interacts with the CMV 1a protein and have designated this gene Tcoi1 (tobacco CMV 1a-interacting protein 1). Tcoi1 specifically interacted with the methyltransferase domain of CMV 1a, and the expression of Tcoi1 was increased by CMV inoculation. Biochemical studies revealed that the interaction of Tcoi1 with CMV 1a protein was direct and that Tcoi1 methylated CMV 1a protein both in vitro and in vivo. The CMV 1a binding activity of Tcoi1 is in the C-terminal domain, which shows the methyltransferase activity. The overexpression of Tcoi1 enhanced the CMV infection, while the reduced expression of Tcoi1 decreased virus infectivity. These results suggest that Tcoi1 controls the propagation of CMV through an interaction with the CMV 1a protein.
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