ArticleInternational journal of pharmaceutics2008
Chemical method to enhance transungual transport and iontophoresis efficiency.
Article in International journal of pharmaceutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Nail Peeling with Glycolic Acid 50%: A Prospective Study of 20 Cases.Skin appendage disorders · 2021Article
- Iontophoresis to Overcome the Challenge of Nail Permeation: Considerations and Optimizations for Successful Ungual Drug Delivery.The AAPS journal · 2021Review
- Potential of Naftifine Application for Transungual Delivery.Molecules (Basel, Switzerland) · 2020Article
- Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride.Materials (Basel, Switzerland) · 2019Article
- Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases.Mycoses · 2017Review
- Formulation development and optimization of transungual drug delivery system of terbinafine hydrochloride for the treatment of onychomycosis.Drug delivery and translational research · 2016Article
- Size and Charge Dependence of Ion Transport in Human Nail Plate.Journal of pharmaceutical sciences · 2016Article
- Diffusion of uncharged solutes through human nail plate.Pharmaceutical development and technology · 2016Article
- Lateral drug diffusion in human nails.AAPS PharmSciTech · 2014Article
- Hydroxypropyl- β -cyclodextrin: A Novel Transungual Permeation Enhancer for Development of Topical Drug Delivery System for Onychomycosis.Journal of drug delivery · 2014Article
- Effects of organic solvents on the barrier properties of human nail.Journal of pharmaceutical sciences · 2011Article
- Iontophoretic terbinafine HCL 1.0% delivery across porcine and human nails.Mycopathologia · 2010Article
- Influence of pH on transungual passive and iontophoretic transport.Journal of pharmaceutical sciences · 2010Article
- Time-dependent electrical properties of human nail upon hydration in vivo.Journal of pharmaceutical sciences · 2010Article
- Iontophoretically enhanced ciclopirox delivery into and across human nail plate.Journal of pharmaceutical sciences · 2009Article
- An ex vivo toe model used to assess applicators for the iontophoretic ungual delivery of terbinafine.Pharmaceutical research · 2009Article
- Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail.Pharmaceutical research · 2009Article
- Glycolic Acid peels for nail rejuvenation.Journal of cutaneous and aesthetic surgeryArticle
- Dermatologist Driven Aesthetic Nail Enhancement.Indian dermatology online journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transungual transport is hindered by the inherent small effective pore size of the nail even when it is fully hydrated. The objectives of this study were to determine the effects of chemical enhancers thioglycolic acid (TGA), glycolic acid (GA), and urea (UR) on transungual transport and iontophoresis efficiency. In vitro passive and iontophoretic transport experiments of model permeants mannitol (MA), UR, and tetraethylammonium (TEA) ion across the fully hydrated, enhancer-treated and untreated human nail plates were performed in phosphate-buffered saline. The transport experiments consisted of several stages, alternating between passive and anodal iontophoretic transport at 0.1mA. Nail water uptake experiments were conducted to determine the water content of the enhancer-treated nails. The effects of the enhancers on transungual electroosmosis were also evaluated. Nails treated with GA and UR did not show any transport enhancement. Treatment with TGA at 0.5M enhanced passive and iontophoretic transungual transport of MA, UR, and TEA. Increasing the TGA concentration to 1.8M did not further increase TEA iontophoresis efficiency. The effect of TGA on the nail plates was irreversible. The present study shows the possibility of using a chemical enhancer to reduce transport hindrance in the nail plate and thus enhance passive and iontophoretic transungual transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.