ArticleJournal of women's health (2002)2008
Lipid-lowering medication use and aggression scores in women: a report from the NHLBI-sponsored WISE study.
Article in Journal of women's health (2002), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies.Frontiers in psychiatry · 2021Pooled it
- The impact of statins on psychological wellbeing: a systematic review and meta-analysis.BMC medicine · 2012Pooled it
- Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial.PloS one · 2015Trial
- Statins-From Fungi to Pharmacy.International journal of molecular sciences · 2023Review
- Post-Marketing Surveillance of Statins-A Descriptive Analysis of Psychiatric Adverse Reactions in EudraVigilance.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Update on Statin Treatment in Patients with Neuropsychiatric Disorders.Life (Basel, Switzerland) · 2021Review
- Therapeutic Strategies for Treatment of Inflammation-related Depression.Current neuropharmacology · 2018Review
- Article
- Article
- Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series.Drug safety - case reports · 2016Article
- Sex-Related Disparities in Criminal Justice and HIV Treatment Outcomes: A Retrospective Cohort Study of HIV-Infected Inmates.American journal of public health · 2015Article
- Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel.Archives of medical science : AMS · 2015Article
- Revisiting the J shaped curve, exploring the association between cardiovascular risk factors and concurrent depressive symptoms in patients with cardiometabolic disease: Findings from a large cross-sectional study.BMC cardiovascular disorders · 2014Article
- Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management.CNS drugs · 2014Review
- First-degree relatives with behavioural adverse effects on statins.BMJ case reports · 2011Article
- Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2008Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimThe aim of this study was to examine the association between the use of lipid-lowering medication and aggressive responding, hostility, cynicism, and depression scores in women undergoing coronary angiography.
methodsThe cohort included 498 women from the National Heart, Lung and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. WISE is a four-center study of women with chest pain who underwent quantitative coronary angiography for suspected myocardial ischemia. The psychosocial indices included the Cook Medley Hostility questionnaire, measuring aggression, hostility, and cynicism, and the Beck Depression Inventory (BDI).
resultsCompared to those not on lipid-lowering medication, women receiving lipid-lowering pharmacotherapy were older (62 vs. 55 years, p < 0.001) and had more hypertension, dyslipidemia, diabetes, and coronary artery disease (CAD, defined as > or =50% stenoses in at least one epicardial artery) (all p < 0.003). Women on lipid-lowering medication had higher aggressive responding scores than those not on medication, 3.0 +/- 1.8 vs. 2.7 +/- 1.7, respectively (age-adjusted p < 0.003). This association persisted after adjustment for coronary risk factors, education, and extent of angiographic disease (CAD) (p < 0.005), and after exclusion of women using psychotropic medications (p < 0.001). Hostility, cynicism, and depression scores did not differ by medication use.
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