ArticleNano letters2008
Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors.
Article in Nano letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Past, Present, and Future of Affinity-based Cell Separation Technologies.Acta biomaterialia · 2020Review
- Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction.Communications biology · 2020Article
- Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs).Advanced drug delivery reviews · 2018Review
- Fundamentals and application of magnetic particles in cell isolation and enrichment: a review.Reports on progress in physics. Physical Society (Great Britain) · 2015Review
- A cell rolling cytometer reveals the correlation between mesenchymal stem cell dynamic adhesion and differentiation state.Lab on a chip · 2014Article
- Nanoparticles and their applications in cell and molecular biology.Integrative biology : quantitative biosciences from nano to macro · 2014Review
- Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns.Scientific reports · 2013Article
- Dimethylsulfoxide exposure modulates HL-60 cell rolling interactions.Bioscience reports · 2012Article
- Cell sorting by deterministic cell rolling.Lab on a chip · 2012Article
- Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates.Biophysical journal · 2012Article
- Studying cell rolling trajectories on asymmetric receptor patterns.Journal of visualized experiments : JoVE · 2011Article
- Examining the lateral displacement of HL60 cells rolling on asymmetric P-selectin patterns.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Biomechanics of leukocyte rolling.Biorheology · 2011Review
- A semianalytical model to study the effect of cortical tension on cell rolling.Biophysical journal · 2010Article
- Microfluidics for cell separation.Medical & biological engineering & computing · 2010Review
- Direct biophotolithographic method for generating substrates with multiple overlapping biomolecular patterns and gradients.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Targeted delivery of therapeutics to endothelium.Cell and tissue research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We envisioned that label-free control of the transport of cells in two dimensions through receptor-ligand interactions would enable simple separation systems that are easy to implement yet retain the specificity of receptor-ligand interactions. Here we demonstrate nanomechanical control of cell transport in two dimensions via transient receptor-ligand adhesive bonds by patterning of receptors that direct cell rolling through an edge effect. HL-60 cells rolling on P-selectin receptor patterns were deflected at angles of 5-10 degrees with respect to their direction of travel. Absence of this effect in the case of rigid microsphere models of cell rolling suggests that this two-dimensional motion depends on nanomechanical properties of the rolling cell. This work suggests the feasibility of simple continuous-flow microfluidic cell separation systems that minimize processing steps and yet retain the specificity of receptor-ligand interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.