ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2008
Live images of RNA polymerase II transcription units.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Anomalous coarsening of coalescing nucleoli in human cells.Biophysical journal · 2024Article
- Imaging the dynamics of transcription loops in living chromosomes.Chromosoma · 2018Article
- Isolation of Giant Lampbrush Chromosomes from Living Oocytes of Frogs and Salamanders.Journal of visualized experiments : JoVE · 2016Article
- Precocious detection on amphibian oocyte lampbrush chromosomes of subtle changes in the cellular localisation of the Ro52 protein induced by in vitro culture.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein.Journal of molecular biology · 2011Article
- Cajal body surveillance of U snRNA export complex assembly.The Journal of cell biology · 2010Article
- Examining the contents of isolated Xenopus germinal vesicles.Methods (San Diego, Calif.) · 2010Article
- Lampbrush chromosomes enable study of cohesin dynamics.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus of an amphibian oocyte can be manually isolated in mineral oil where it maintains all its activities for several hours. These undisrupted (live) nuclei have been used successfully in recent years to analyze the dynamic organization of several non-chromosomal nuclear organelles. Here, we describe an improved procedure for imaging an oil-isolated nucleus by light microscopy and we use it to produce the very first images of lampbrush chromosomes in an in vivo-like condition. These chromosomes are morphologically identical to those observed in conventional nuclear spread preparations. Importantly, their lateral loops, which are active RNA polymerase II transcription units, are readily distinguished by differential interference contrast microscopy.
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