ArticleDigestive diseases and sciences2008
Antral inflammatory cells, gastric emptying, and electrogastrography in pediatric functional dyspepsia.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Duodenal Microbiome in Pediatric Functional Dyspepsia
Predictors of Clinical Response to Montelukast in Children With Functional Dyspepsia
Double-blind, Placebo-controlled, Cross-over Trial of Ketotifen in Children and Adolescents With Functional Dyspepsia in Association With Duodenal Eosinophilia
GpCRC Pediatric Gastroparesis Registry 2: Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants With Symptoms of Gastroparesis
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- A Pilot Study of Ketotifen in Patients Aged 8-17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia.Paediatric drugs · 2024Trial
- Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia.BMC research notes · 2012Trial
- Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics.BMC gastroenterology · 2009Trial
- Associations of Meal-Related and Somatic Symptoms With Mucosal Eosinophil and Mast Cell Counts in Youth With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Article
- Antibiotic duration and gastric dysmotility in preterm neonates.Journal of pediatric gastroenterology and nutrition · 2024Article
- Navigating through 65 years of insights: lessons learned on functional abdominal pain in children.European journal of pediatrics · 2024Review
- Percutaneous Electrical Nerve Field Stimulation in Children and Adolescents With Functional Dyspepsia-Integrating a Behavioral Intervention.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia.Journal of neurogastroenterology and motility · 2022Article
- Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake.Nutrients · 2022Article
- Allergy-related diseases in childhood and risk for abdominal pain-related functional gastrointestinal disorders at 16 years-a birth cohort study.BMC medicine · 2021Article
- Vagal gut-brain signaling mediates amygdaloid plasticity, affect, and pain in a functional dyspepsia model.JCI insight · 2021Article
- A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning.BMC gastroenterology · 2020Article
- How does one choose the appropriate pharmacotherapy for pediatric patients with functional dyspepsia?Expert opinion on pharmacotherapy · 2019Article
- Quantitative Analysis of Distribution of the Gastrointestinal Tract Eosinophils in Childhood Functional Abdominal Pain Disorders.Journal of neurogastroenterology and motility · 2018Article
- Observational
- Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria.Journal of neurogastroenterology and motility · 2016Article
- The Gastric and Duodenal Eosinophilia in Functional Dyspepsia.Journal of neurogastroenterology and motility · 2016Article
- Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia.World journal of gastrointestinal pharmacology and therapeutics · 2014Review
- Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia.World journal of gastrointestinal pharmacology and therapeutics · 2013Review
- Current status of multichannel electrogastrography and examples of its use.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of the current study were to determine the activation states of antral eosinophils and mast cells and to evaluate the interactions of antral inflammatory cells with gastric emptying and electrogastrography (EGG) in 30 pediatric patients with functional dyspepsia. Eosinophil degranulation was moderate in 42% and extensive in 54% of patients. Mast cell degranulation was > 50% in 81% of patients. Elevated mast cell density was associated with slower one hour gastric emptying and increased preprandial dysrhythmia. Mast cell density correlated with the preprandial percentage tachygastria. CD3+ cell density correlated with the preprandial percentage tachygastria also, but only in patients with increased eosinophil density. In conclusion, antral eosinophils and mast cells are significantly activated in pediatric functional dyspepsia. Mast cell density is associated with delayed gastric emptying and preprandial dysrhythmia, suggesting that there may be an interaction between antral inflammation and gastric electromechanical dysfunction in the pathophysiology of pediatric functional dyspepsia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.