ArticleCurrent microbiology2008
Aminoglycoside-resistance mechanisms in multidrug-resistant Staphylococcus aureus clinical isolates.
Article in Current microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Comprehensive in silico genomics analysis of global trends and host-specific emergence of aminoglycoside resistance in Staphylococcus aureus: a One-Health perspective.BMC microbiology · 2026Pooled it
- Breaking the antimicrobial resistance dilemma: marine natural products, a treasure trove for the development of new anti-Marine life science & technology · 2026Review
- Molecular Epidemiology, Clinical Manifestations, Decolonization Strategies, and Treatment Options of Methicillin-Susceptible Staphylococcus Aureus Infection in Neonates.International journal of molecular sciences · 2025Review
- Prevalence and molecular characterization of multidrug-resistant coagulase negative staphylococci from urban wastewater in Delhi-NCR, India.Archives of microbiology · 2024Article
- Isolation and Genomic Analysis of a Case ofMicroorganisms · 2024Article
- Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes inFrontiers in cellular and infection microbiology · 2024Article
- Antibacterial sensitizers from natural plants: A powerful weapon against methicillin-resistantFrontiers in pharmacology · 2023Review
- Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022Review
- Mechanisms of Antibiotic Resistance in Important Gram-Positive and Gram-Negative Pathogens and Novel Antibiotic Solutions.Antibiotics (Basel, Switzerland) · 2021Review
- Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.PLoS computational biology · 2020Article
- Frequency distribution of genes encoding aminoglycoside modifying enzymes in uropathogenic E. coli isolated from Iranian hospital.BMC research notes · 2014Article
- Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs.Frontiers in microbiology · 2013Article
- Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aminoglycoside resistance in six clinically isolated Staphylococcus aureus was evaluated. Genotypical examination revealed that three isolates (HLGR-10, HLGR-12, and MSSA-21) have aminoglycoside-modifying enzyme (AME) coding genes and another three (GRSA-2, GRSA-4, and GRSA-6) lacked these genes in their genome. Whereas isolates HLGR-10 and HLGR-14 possessed bifunctional AME coding gene aac(6')-aph(2''), and aph(3')-III and showed high-level resistance to gentamycin and streptomycin, MSSA-21 possessed aph(3')-III and exhibited low resistance to gentamycin, streptomycin, and kanamycin. The remaining three isolates (GRSA-2, GRSA-4, and GRSA-6) exhibited low resistance to all the aminoglycosides because they lack aminoglycoside-modifying enzyme coding genes in their genome. The transmission electron microscopy of the three isolates revealed changes in cell size, shape, and septa formation, supporting the view that the phenomenon of adaptive resistance is operative in these isolates.
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