ArticlePediatric nephrology (Berlin, Germany)2008
Metabonomics of acute kidney injury in children after cardiac surgery.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Biomarkers of acute kidney injury after pediatric cardiac surgery: a meta-analysis of diagnostic test accuracy.European journal of pediatrics · 2022Pooled it
- Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics.PloS one · 2013Trial
- Advances in metabolomics profiling of pediatric kidney diseases: A review.Biomolecules & biomedicine · 2024Review
- Urinary metabolomics to develop predictors for pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2022Article
- New Insights from Metabolomics in Pediatric Renal Diseases.Children (Basel, Switzerland) · 2022Review
- Plasma Metabolites-Based Prediction in Cardiac Surgery-Associated Acute Kidney Injury.Journal of the American Heart Association · 2021Article
- Urinary NMR Profiling in Pediatric Acute Kidney Injury-A Pilot Study.International journal of molecular sciences · 2020Article
- Acute kidney injury overview: From basic findings to new prevention and therapy strategies.Pharmacology & therapeutics · 2019Review
- Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.BMC nephrology · 2019Article
- Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis.Kidney international reports · 2019Article
- Urine metabolites are associated with glomerular lesions in type 2 diabetes.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- [Values of combination of urinary L-FABP and NGAL in early diagnosis of acute kidney injury after cardiac surgery in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Incidence and Outcome of Acute Cardiorenal Syndrome in Hospitalized Children.Indian journal of pediatrics · 2017Article
- Mitogen-Activated Protein Kinase 14 Promotes AKI.Journal of the American Society of Nephrology : JASN · 2017Article
- The nephrologist of tomorrow: towards a kidney-omic future.Pediatric nephrology (Berlin, Germany) · 2017Review
- Sputum metabolomic profiling of bronchial asthma based on quadruple time-of-flight mass spectrometry.International journal of clinical and experimental pathology · 2017Article
- Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study.Pediatric nephrology (Berlin, Germany) · 2017Article
- Renal injury in neonates: use of "omics" for developing precision medicine in neonatology.Pediatric research · 2017Review
- Early detection of acute kidney injury after pediatric cardiac surgery.Progress in pediatric cardiology · 2016Article
- Metabonomics and intensive care.Critical care (London, England) · 2016Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Acute kidney injury (AKI) is a major complication in children who undergo cardiopulmonary bypass surgery. We performed metabonomic analyses of urine samples obtained from 40 children that underwent cardiac surgery for correction of congenital cardiac defects. Serial urine samples were obtained from each patient prior to surgery and at 4 h and 12 h after surgery. AKI, defined as a 50% or greater rise in baseline level of serum creatinine, was noted in 21 children at 48-72 h after cardiac surgery. The principal component analysis of liquid chromatography/mass spectrometry (LC/MS) negative ionization data of the urine samples obtained 4 h and 12 h after surgery from patients who develop AKI clustered away from patients who did not develop AKI. The LC/MS peak with mass-to-charge ratio (m/z) 261.01 and retention time (tR) 4.92 min was further analyzed by tandem mass spectrometry (MS/MS) and identified as homovanillic acid sulfate (HVA-SO4), a dopamine metabolite. By MS single-reaction monitoring, the sensitivity was 0.90 and specificity was 0.95 for a cut-off value of 24 ng/microl for HVA-SO4 at 12 h after surgery. We concluded that urinary HVA-SO4 represents a novel, sensitive, and predictive early biomarker of AKI after pediatric cardiac surgery.
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Registered trials
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