ReviewPediatric nephrology (Berlin, Germany)2008
Diabetes and chronic kidney disease: lessons from the Pima Indians.
Review in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Pathology identifies glomerular treatment targets in diabetic nephropathy.Kidney research and clinical practice · 2018Review
- Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology.Clinical kidney journal · 2017Article
- Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy.Scientific reports · 2016Article
- Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Toll-like receptor 2 and type 2 diabetes.Cellular & molecular biology letters · 2016Review
- Temporal profile of diabetic nephropathy pathologic changes.Current diabetes reports · 2013Review
- Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study.PloS one · 2013Article
- Estimating individual glomerular volume in the human kidney: clinical perspectives.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Left ventricular hypertrophy and geometry in type 2 diabetes patients with chronic kidney disease. An echocardiographic study.Cardiovascular journal of Africa · 2012Article
- Pathophysiology of the diabetic kidney.Comprehensive Physiology · 2011Review
- Sodium-glucose transport: role in diabetes mellitus and potential clinical implications.Current opinion in nephrology and hypertension · 2010Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Although diabetic nephropathy is a very rare cause of kidney failure during childhood, the underlying events leading to progressive kidney injury begin during childhood in many patients with type 1 diabetes mellitus (T1DM) and in increasing numbers of children with type 2 diabetes mellitus (T2DM). The Pima Indians of Arizona represent an exceptionally thoroughly studied population suffering from very high rates of T2DM and diabetic nephropathy (T2DN). This population well illustrates the often inexorable progression from glomerular hyperfiltration to microalbuminuria to overt proteinuria and loss of glomerular filtration rate (GFR), paralleled by the accumulation of mesangial matrix and basement membrane, glomerular hypertrophy, loss of podocytes and eventual glomerular sclerosis and interstitial fibrosis. Structural changes quantitatively account for the loss of GFR in T2DN. The mechanism of albuminuria (and its relationship to GFR loss) is much less clear. There is strong functional and structural evidence for defects in glomerular size-selectivity (shunts) due to podocyte pathology, but only beginning at relatively high levels of proteinuria (albumin/creatinine ratios > 3000 mg/g). Podocyte loss accompanies, and may underlie, the loss of glomeruli to sclerosis. At this point, most evidence in humans suggests detachment of intact podocytes from the glomerular basement membrane, rather than apoptosis, as the predominant mechanism of podocyte loss.
Indexed as
Identifiers
18320236What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.