ArticlePloS one2008
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mechanotransduction through T cell receptors: consensus, controversies and future outlooks.Experimental & molecular medicine · 2026Review
- Emerging Role of T-cell Receptor Constant β Chain-1 (TRBC1) Expression in the Flow Cytometric Diagnosis of T-cell Malignancies.International journal of molecular sciences · 2021Review
- Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol.Frontiers in cell and developmental biology · 2020Review
- Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.Science advances · 2015Article
- Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus.Scientific reports · 2015Article
- Insights into the initiation of TCR signaling.Nature immunology · 2014Review
- Article
- An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.PLoS pathogens · 2013Article
- IgG Fab fragments forming bivalent complexes by a conformational mechanism that is reversible by osmolytes.The Journal of biological chemistry · 2012Article
- Meeting report: Signal transduction meets systems biology.Cell communication and signaling : CCS · 2012Article
- TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.Frontiers in immunology · 2012Article
- Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mechanisms for T cell receptor triggering.Nature reviews. Immunology · 2011Review
- Stoichiometry and intracellular fate of TRIM-containing TCR complexes.Cell communication and signaling : CCS · 2010Article
- Nck adapter proteins: functional versatility in T cells.Cell communication and signaling : CCS · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How the T cell antigen receptor (TCR) discriminates between molecularly related peptide/Major Histocompatibility Complex (pMHC) ligands and converts this information into different possible signaling outcomes is still not understood. One current model proposes that strong pMHC ligands, but not weak ones, induce a conformational change in the TCR. Evidence supporting this comes from a pull-down assay that detects ligand-induced binding of the TCR to the N-terminal SH3 domain of the adapter protein Nck, and also from studies with a neoepitope-specific antibody. Both methods rely on the exposure of a polyproline sequence in the CD3epsilon subunit of the TCR, and neither indicates whether the conformational change is transmitted to other CD3 subunits. Using a protease-sensitivity assay, we now show that the cytoplasmic tails of CD3epsilon and CD3zeta subunits become fully protected from degradation upon TCR triggering. These results suggest that the TCR conformational change is transmitted to the tails of CD3epsilon and CD3zeta, and perhaps all CD3 subunits. Furthermore, the resistance to protease digestion suggests that CD3 cytoplasmic tails adopt a compact structure in the triggered TCR. These results are consistent with a model in which transduction of the conformational change induced upon TCR triggering promotes condensation and shielding of the CD3 cytoplasmic tails.
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