SynthesisPLoS neglected tropical diseases2008
Decision-model estimation of the age-specific disability weight for schistosomiasis japonica: a systematic review of the literature.
Synthesis in PLoS neglected tropical diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Neglected tropical diseases and vitamin B12: a review of the current evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2018Pooled it
- Neglected tropical diseases: survey and geometry of randomised evidence.BMJ (Clinical research ed.) · 2012Pooled it
- Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review.PLoS neglected tropical diseases · 2011Pooled it
- A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil.PLoS neglected tropical diseases · 2011Trial
- A randomized, double-blind, placebo-controlled trial of safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in China.Bulletin of the World Health Organization · 2008Trial
- Evaluation of School-Based Health Education Intervention on the Incidence of Soil-Transmitted Helminths in Pupils of Rural Communities of Eastern Kogi State, North Central Nigeria.Journal of parasitology research · 2022Article
- Humoral antimalaria immune response in Nigerian children exposed to helminth and malaria parasites.Frontiers in immunology · 2022Article
- HDL Receptor inFrontiers in cell and developmental biology · 2022Review
- Edaphic and climatic factors influence on the distribution of soil transmitted helminths in Kogi East, Nigeria.Scientific reports · 2021Article
- Analysis of Environmental DNA and Edaphic Factors for the Detection of the Snail Intermediate HostPathogens (Basel, Switzerland) · 2019Article
- Estimation of disability weight for paragonimiasis: a systematic analysis.Infectious diseases of poverty · 2018Review
- Burden of intestinal helminths and associated factors three years after initiation of mass drug administration in Arbaminch Zuria district, Southern Ethiopia.BMC infectious diseases · 2018Article
- Probiotics for the Control of Helminth Zoonosis.Journal of veterinary medicine · 2018Review
- Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province, Peoples' Republic of China using a geographical detector method.Infectious diseases of poverty · 2017Article
- Ethiopia Schistosomiasis and Soil-Transmitted Helminthes Control Programme: Progress and Prospects.Ethiopian medical journal · 2017Article
- Review
- Exploring the contribution of host susceptibility to epidemiological patterns of Schistosoma japonicum infection using an individual-based model.The American journal of tropical medicine and hygiene · 2015Article
- Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP.Journal of biomedical research · 2015Review
- Spatio-temporal transmission and environmental determinants of Schistosomiasis Japonica in Anhui Province, China.PLoS neglected tropical diseases · 2015Article
- Co-endemicity of Plasmodium falciparum and Intestinal Helminths Infection in School Age Children in Rural Communities of Kwara State Nigeria.PLoS neglected tropical diseases · 2015Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Schistosomiasis is among the most prevalent parasitic infections worldwide. However, current Global Burden of Disease (GBD) disability-adjusted life year estimates indicate that its population-level impact is negligible. Recent studies suggest that GBD methodologies may significantly underestimate the burden of parasitic diseases, including schistosomiasis. Furthermore, strain-specific disability weights have not been established for schistosomiasis, and the magnitude of human disease burden due to Schistosoma japonicum remains controversial. We used a decision model to quantify an alternative disability weight estimate of the burden of human disease due to S. japonicum. We reviewed S. japonicum morbidity data, and constructed decision trees for all infected persons and two age-specific strata, <15 years (y) and > or =15 y. We conducted stochastic and probabilistic sensitivity analyses for each model. Infection with S. japonicum was associated with an average disability weight of 0.132, with age-specific disability weights of 0.098 (<15 y) and 0.186 (> or =15 y). Re-estimated disability weights were seven to 46 times greater than current GBD measures; no simulations produced disability weight estimates lower than 0.009. Nutritional morbidities had the greatest contribution to the S. japonicum disability weight in the <15 y model, whereas major organ pathologies were the most critical variables in the older age group. GBD disability weights for schistosomiasis urgently need to be revised, and species-specific disability weights should be established. Even a marginal increase in current estimates would result in a substantial rise in the estimated global burden of schistosomiasis, and have considerable implications for public health prioritization and resource allocation for schistosomiasis research, monitoring, and control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.