Evidence map›Paper›PMID 18319728›Full record

ReviewNature reviews. Neuroscience2008

Noise in the nervous system.

A Aldo Faisal, Luc P J Selen, Daniel M Wolpert

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06065410 (Research Assistant Doctor), which is not on this map. Cited by 1,209 papers.

0numbers the graph read from it
0cells of the map it votes in
1,209citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06065410 nacompletednot on this mapstarted 2022, after this paper: background citation

Research Assistant Doctor

TypeinterventionalSponsorGazi UniversityRan2022 to 2023Enrolled40ConditionsKnee OsteoarthritisArmsBaseline, Intrinsic focus, White noise, environmental sound
3 · Its place in the literature

Who cites it

1,209 citing papers in PubMed.

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  13. Testing quantum-like markers in neural dynamics.Journal of computational neuroscience · 2026
    Review
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1,149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A Aldo FaisalComputational and Biological Learning Lab, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK. aaf23@cam.ac.uk
Luc P J Selen
Daniel M Wolpert

Funding

Wellcome Trust 077730
6 · The paper itself

Abstract

Noise--random disturbances of signals--poses a fundamental problem for information processing and affects all aspects of nervous-system function. However, the nature, amount and impact of noise in the nervous system have only recently been addressed in a quantitative manner. Experimental and computational methods have shown that multiple noise sources contribute to cellular and behavioural trial-to-trial variability. We review the sources of noise in the nervous system, from the molecular to the behavioural level, and show how noise contributes to trial-to-trial variability. We highlight how noise affects neuronal networks and the principles the nervous system applies to counter detrimental effects of noise, and briefly discuss noise's potential benefits.

Indexed as

Nervous SystemNervous System Physiological PhenomenaNoiseAnimalsHumansInformation TheoryModels, NeurologicalNerve NetNeural Networks, ComputerNeural Pathways

Identifiers

PMID18319728
PMCPMC2631351

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.