ArticleThe Journal of clinical endocrinology and metabolism2008
Visceral obesity and plasma glucose-insulin homeostasis: contributions of interleukin-6 and tumor necrosis factor-alpha in men.
Article in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01410604. Cited by 66 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammatory Mediators in Obese Adolescents With Insulin Resistance Following Metformin Treatment: Controlled Randomized Clinical Trial
Who cites it
66 citing papers in PubMed, 157 citations in OpenAlex.
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- Effects of chronic exercise training on inflammatory markers in Australian overweight and obese individuals in a randomized controlled trial.Inflammation · 2013Trial
- Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women.Obesity (Silver Spring, Md.) · 2011Trial
- Omentectomy added to Roux-en-Y gastric bypass surgery: a randomized, controlled trial.Surgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryTrial
- Lipedema as a disorder of adipose tissue heterogeneity: insights from single-cell and spatial transcriptomics.Frontiers in cell and developmental biology · 2026Review
- Multiple Ectopic calcifications in end-stage renal disease: role of inflammation and partial reversibility with intensified peritoneal dialysis-a case report.BMC nephrology · 2025Article
- Coexistence of high visceral fat area and sarcopenia is associated with atherosclerotic markers in old-old patients with diabetes: A cross-sectional study.Journal of diabetes investigation · 2024Article
- The Role of Glucose, Insulin and Body Fat in Assessment of Bone Mineral Density and Trabecular Bone Score in Women with Functional Hypothalamic Amenorrhea.Journal of clinical medicine · 2024Article
- Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women.Journal of clinical medicine · 2024Article
- Interaction between peripheral blood mononuclear cells andFrontiers in immunology · 2024Article
- 1-Marine drugs · 2023Article
- Low-dose of phenolic rich extract fromFrontiers in nutrition · 2023Article
- Th1/Th2 cytokines profile in overweight/obese young adults and their correlation with airways inflammation.Journal of Taibah University Medical Sciences · 2022Article
- Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Non-Obese Postmenopausal Chinese Women Over 60 Years Old.Frontiers in endocrinology · 2022Article
- Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation.Journal of clinical medicine · 2021Review
- Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography.Frontiers in cellular and infection microbiology · 2021Article
- Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model.Antioxidants (Basel, Switzerland) · 2020Article
- Prospective Study of Long-Term Interrelationships Among Adiposity-Associated Biomarkers in Women.Obesity (Silver Spring, Md.) · 2020Article
- Evaluation of Interleukin-6, Leukotriene B-4, and Nitric Oxide Levels in Exhaled Breath Condensate of Asymptomatic Obese Individuals: Are Obese Patients Under Risk of Developing Asthma?The Eurasian journal of medicine · 2020Article
- A metagenome-wide association study of gut microbiome and visceral fat accumulation.Computational and structural biotechnology journal · 2020Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study examined the relationships of two inflammatory cytokines, IL-6 and TNF-alpha, to visceral adiposity and indices of plasma glucose-insulin homeostasis. RESEARCH DESIGN AND
methodsPlasma levels of IL-6 and TNF-alpha were measured in 189 untreated asymptomatic men (aged 43.7 +/- 7.8 yr; body mass index 29.0 +/- 4.3 kg/m(2); waist girth 98.6 +/- 10.3 cm).
resultsSignificant and positive associations were found between both cytokines with adiposity and adipose tissue distribution indices (0.15 < or = r < 0.32; P < 0.05) as well as plasma glucose-insulin homeostasis variables (0.22 < or = r < 0.28; P <0.05). Comparison of two subgroups, each composed of 32 overweight men (> or =25 kg/m(2)) with similar body mass index values (28.7 kg/m(2) in both groups) but with markedly different levels of visceral adipose tissue (< vs. > or = 130 cm(2)), revealed significant differences only for IL-6 levels (1.42 +/- 1.15 vs. 0.86 +/- 0.52 pg/ml; P < 0.02 for men with high vs. low visceral adipose tissue, respectively). Finally, when subjects were stratified on the basis of their respective concentrations of IL-6 and TNF-alpha (using the 50th percentile of their overall distribution), an ANOVA revealed an independent contribution of IL-6 to the variation of fasting insulin (P < 0.01) and each of these two cytokines to the variation of insulin levels measured after a 75-g oral glucose challenge (P <0.01 for IL-6 and P < 0.05 for TNF-alpha).
conclusionsBecause IL-6 appeared to be clearly associated with visceral adiposity, TNF-alpha rather showed associations with indices of total body fatness. Thus, TNF-alpha may contribute to the insulin resistance of overall obesity, whereas IL-6 may be one of the mediators of the hyperinsulinemic state specifically related to excess visceral adiposity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.