ArticleJournal of cell science2008
Phenotype reversion in fetal human liver epithelial cells identifies the role of an intermediate meso-endodermal stage before hepatic maturation.
Article in Journal of cell science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Mesenchymal Stem Cells Beyond Regenerative Medicine.Frontiers in cell and developmental biology · 2020Review
- Differentiation in stem/progenitor cells along fetal or adult hepatic stages requires transcriptional regulators independently of oscillations in microRNA expression.Experimental cell research · 2018Article
- Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- [Gene expression and functional profiles related to differentiation of human hepatic progenitor cells].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2015Article
- Endogenous antiviral microRNAs determine permissiveness for hepatitis B virus replication in cultured human fetal and adult hepatocytes.Journal of medical virology · 2015Article
- Inflammation rapidly modulates the expression of ALDH1A1 (RALDH1) and vimentin in the liver and hepatic macrophages of rats in vivo.Nutrition & metabolism · 2014Article
- Evidence for a common progenitor of epithelial and mesenchymal components of the liver.Cell death and differentiation · 2013Article
- Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats.Hepatology (Baltimore, Md.) · 2012Article
- Spontaneous origin from human embryonic stem cells of liver cells displaying conjoint meso-endodermal phenotype with hepatic functions.Journal of cell science · 2012Article
- Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.Hepatology (Baltimore, Md.) · 2011Article
- New concepts in liver regeneration.Journal of gastroenterology and hepatology · 2011Article
- The existence of multipotent stem cells with epithelial-mesenchymal transition features in the human liver bud.The international journal of biochemistry & cell biology · 2010Article
- Bone marrow mesenchymal stem cells: historical overview and concepts.Human gene therapy · 2010Review
- Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells.Stem cell research & therapy · 2010Article
- Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice.Hepatology (Baltimore, Md.) · 2009Article
- Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.The American journal of pathology · 2009Article
- Foxl1 is a marker of bipotential hepatic progenitor cells in mice.Hepatology (Baltimore, Md.) · 2009Article
- Quantitative tools for assessing the fate of xenotransplanted human stem/progenitor cells in chimeric mice.XenotransplantationArticle
- Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Understanding the biological potential of fetal stem/progenitor cells will help define mechanisms in liver development and homeostasis. We isolated epithelial fetal human liver cells and established phenotype-specific changes in gene expression during continuous culture conditions. Fetal human liver epithelial cells displayed stem cell properties with multilineage gene expression, extensive proliferation and generation of mesenchymal lineage cells, although the initial epithelial phenotype was rapidly supplanted by meso-endodermal phenotype in culture. This meso-endodermal phenotype was genetically regulated through cytokine signaling, including transforming growth factor beta, bone morphogenetic protein, fibroblast growth factor and other signaling pathways. Reactivation of HNF3alpha (FOXA1) transcription factor, a driver of hepatic specification in the primitive endoderm, indicated that the meso-endodermal phenotype represented an earlier developmental stage of cells. We found that fetal liver epithelial cells formed mature hepatocytes in vivo, including after genetic manipulation using lentiviral vectors, offering convenient assays for analysis of further cell differentiation and fate. Taken together, these studies demonstrate plasticity in fetal liver epithelial stem cells, offer paradigms for defining mechanisms regulating lineage switching in stem cells, and provide potential avenues for regulating cell phenotypes for applications of stem cells, such as for cell therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.