ArticleCritical care (London, England)2008
The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands.
Article in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Impact of hemodynamic goal-directed resuscitation on mortality in adult critically ill patients: a systematic review and meta-analysis.Journal of clinical monitoring and computing · 2018Pooled it
- Bundled care for septic shock: an analysis of clinical trials.Critical care medicine · 2010Pooled it
- Gastric tonometry versus cardiac index as resuscitation goals in septic shock: a multicenter, randomized, controlled trial.Critical care (London, England) · 2009Trial
- Twenty-five years of septic shock hemodynamic resuscitation trials: a conceptual perspective.Critical care (London, England) · 2026Review
- Use of COAnnals of intensive care · 2025Review
- Association of LVV-Hemorphin-7 with Sepsis and Shock: Roles of Cathepsin D and G in Hemoglobin Metabolism in a Prospective ICU Cohort Study.Biomedicines · 2024Article
- Pathophysiology of fluid administration in critically ill patients.Intensive care medicine experimental · 2022Review
- The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis.Diagnostics (Basel, Switzerland) · 2021Review
- Management of sepsis and septic shock in the emergency department.Internal and emergency medicine · 2021Review
- RBC Transfusion Triggers: Is There Anything New?Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Review
- Effects of respiratory rate on venous-to-arterial COEuropean journal of medical research · 2020Article
- Central and Mixed Venous OTurkish journal of anaesthesiology and reanimation · 2020Review
- The Forgotten Hemodynamic (PCO2 Gap) in Severe Sepsis.Critical care research and practice · 2020Article
- Circulatory effects of dexmedetomidine in early sepsis: a randomised controlled experimental study.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Combination of OJournal of thoracic disease · 2019Review
- Endorsing performance measures is a matter of trust.BMJ (Clinical research ed.) · 2018Article
- Comparative evaluation of central venous pressure and sonographic inferior vena cava variability in assessing fluid responsiveness in septic shock.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2016Article
- Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?Intensive care medicine · 2016Article
- Venous-to-arterial carbon dioxide differences and the microcirculation in sepsis.Annals of translational medicine · 2016Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow mixed or central venous saturation (S(c)vO2) can reveal global tissue hypoxia and therefore can predict poor prognosis in critically ill patients. Early goal directed therapy (EGDT), aiming at an ScvO2 >/= 70%, has been shown to be a valuable strategy in patients with sepsis or septic shock and is incorporated in the Surviving Sepsis Campaign guidelines.
methodsIn this prospective observational multi-center study, we determined central venous pressure (CVP), hematocrit, pH, lactate and ScvO2 or SvO2 in a heterogeneous group of critically ill patients early after admission to the intensive care units (ICUs) in three Dutch hospitals.
resultsData of 340 acutely admitted critically ill patients were collected. The mean SvO2 value was > 65% and the mean ScvO2 value was > 70%. With mean CVP of 10.3 +/- 5.5 mmHg, lactate plasma levels of 3.6 +/- 3.6 and acute physiology, age and chronic health evaluation (APACHE II) scores of 21.5 +/- 8.3, the in-hospital mortality of the total heterogeneous population was 32.0%. A subgroup of septic patients (n = 125) showed a CVP of 9.8 +/- 5.4 mmHg, mean ScvO2 values of 74.0 +/- 10.2%, where only 1% in this subgroup revealed a ScvO2 value < 50%, and lactate plasma levels of 2.7 +/- 2.2 mmol/l with APACHE II scores 20.9 +/- 7.3. Hospital mortality of this subgroup was 26%.
conclusionThe incidence of low ScvO2 values for acutely admitted critically ill patients is low in Dutch ICUs. This is especially true for patients with sepsis/septic shock.
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