ArticleAnnals of human genetics2008
Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.
Article in Annals of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Genome-wide interaction study identifies RCBTB1 as a modifier for smoking effect on carotid intima-media thickness.Arteriosclerosis, thrombosis, and vascular biology · 2014Pooled it
- A Variant in COX-2 Gene Is Associated with Left Main Coronary Artery Disease and Clinical Outcomes of Coronary Artery Bypass Grafting.BioMed research international · 2017Trial
- Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice.NPJ Regenerative medicine · 2025Article
- The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL.Science advances · 2024Article
- 1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit.International journal of molecular sciences · 2024Article
- Left Main Coronary Artery Disease: A Contemporary Review of Diagnosis and Management.Reviews in cardiovascular medicine · 2024Review
- Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- Genome-wide methylation patterns in Marfan syndrome.Clinical epigenetics · 2021Article
- Cells of the adult human heart.Nature · 2020Article
- Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.Journal of molecular biology · 2020Article
- Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse.Frontiers in neuroscience · 2017Article
- Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship.PloS one · 2016Article
- A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.Journal of cardiovascular translational research · 2015Review
- A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease.Biochemistry research international · 2014Article
- Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.Human genetics · 2013Article
- A rare 3q13.31 microdeletion including GAP43 and LSAMP genes.Molecular cytogenetics · 2013Article
- The genetic basis for survivorship in coronary artery disease.Frontiers in genetics · 2013Article
- Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.Human genetics · 2011Article
- Vitamin D receptor gene as a candidate gene for Parkinson disease.Annals of human genetics · 2011Article
- Genomics of premature atherosclerotic vascular disease.Current atherosclerosis reports · 2010Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
Previous association mapping on chromosome 3q13-21 detected evidence for association at the limbic system-associated membrane protein (LSAMP) gene in individuals with late-onset coronary artery disease (CAD). LSAMP has never been implicated in the pathogenesis of CAD. We sought to thoroughly characterize the association and the gene. Non-redundant single nucleotide polymorphisms (SNPs) across the gene were examined in an initial dataset (168 cases with late-onset CAD, 149 controls). Stratification analysis on left main CAD (N = 102) revealed stronger association, which was further validated in a validation dataset (141 cases with left main CAD, 215 controls), a third control dataset (N = 255), and a family-based dataset (N = 2954). A haplotype residing in a novel alternative transcript of the LSAMP gene was significant in all independent case-control datasets (p = 0.0001 to 0.0205) and highly significant in the joint analysis (p = 0.00004). Lower expression of the novel alternative transcript was associated with the risk haplotype (p = 0.0002) and atherosclerosis burden in human aortas (p = 0.0001). Furthermore, silencing LSAMP expression in human aortic smooth muscle cells (SMCs) substantially augmented SMC proliferation (p<0.01). Therefore, the risk conferred by the LSAMP haplotype appears to be mediated by LSAMP down-regulation, which may promote SMC proliferation in the arterial wall and progression of atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.