ArticleMolecular genetics and genomics : MGG2008
Transcriptomics and adaptive genomics of the asymptomatic bacteriuria Escherichia coli strain 83972.
Article in Molecular genetics and genomics : MGG, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Genetic risk for recurrent urinary tract infections in humans: a systematic review.Journal of biomedicine & biotechnology · 2010Pooled it
- Less is more: the lack of autoinducer-2-dependent quorum sensing promotes competitive fitness ofFrontiers in cellular and infection microbiology · 2025Article
- Phenotypic Assessment of Clinical Escherichia coli Isolates as an Indicator for Uropathogenic Potential.mSystems · 2022Article
- "Omics" Technologies - What Have They Told Us About UropathogenicFrontiers in cellular and infection microbiology · 2022Review
- Genome-wide analysis of fitness-factors in uropathogenicMicrobial genomics · 2021Article
- Evolution of Polymyxin Resistance Regulates Colibactin Production inACS chemical biology · 2021Article
- Plasmids shape the diverse accessory resistomes ofAccess microbiology · 2021Article
- The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin.mSphere · 2020Article
- ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli.mSphere · 2020Article
- Colibactin: More Than a New Bacterial Toxin.Toxins · 2018Review
- Bacterial Suppression of RNA Polymerase II-Dependent Host Gene Expression.Pathogens (Basel, Switzerland) · 2016Article
- Virulence and Fitness Determinants of Uropathogenic Escherichia coli.Microbiology spectrum · 2015Review
- Identification of genes important for growth of asymptomatic bacteriuria Escherichia coli in urine.Infection and immunity · 2012Article
- Variation in endogenous oxidative stress in Escherichia coli natural isolates during growth in urine.BMC microbiology · 2012Article
- Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli.Infection and immunity · 2012Article
- Asymptomatic bacteriuria: when the treatment is worse than the disease.Nature reviews. Urology · 2011Review
- Functional genomics of probiotic Escherichia coli Nissle 1917 and 83972, and UPEC strain CFT073: comparison of transcriptomes, growth and biofilm formation.Molecular genetics and genomics : MGG · 2010Article
- Escherichia coli global gene expression in urine from women with urinary tract infection.PLoS pathogens · 2010Article
- A virulent parent with probiotic progeny: comparative genomics of Escherichia coli strains CFT073, Nissle 1917 and ABU 83972.Molecular genetics and genomics : MGG · 2010Article
- Use of zebrafish to probe the divergent virulence potentials and toxin requirements of extraintestinal pathogenic Escherichia coli.PLoS pathogens · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli strains are the major cause of urinary tract infections in humans. Such strains can be divided into virulent, UPEC strains causing symptomatic infections, and asymptomatic, commensal-like strains causing asymptomatic bacteriuria, ABU. The best-characterized ABU strain is strain 83972. Global gene expression profiling of strain 83972 has been carried out under seven different sets of environmental conditions ranging from laboratory minimal medium to human bladders. The data reveal highly specific gene expression responses to different conditions. A number of potential fitness factors for the human urinary tract could be identified. Also, presence/ absence data of the gene expression was used as an adaptive genomics tool to model the gene pool of 83972 using primarily UPEC strain CFT073 as a scaffold. In our analysis, 96% of the transcripts filtered present in strain 83972 can be found in CFT073, and genes on six of the seven pathogenicity islands were expressed in 83972. Despite the very different patient symptom profiles, the two strains seem to be very similar. Genes expressed in CFT073 but not in 83972 were identified and can be considered as virulence factor candidates. Strain 83972 is a deconstructed pathogen rather than a commensal strain that has acquired fitness properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.