ArticlePlant cell reports2008
Arabidopsis R2R3-MYB transcription factor AtMYB60 functions as a transcriptional repressor of anthocyanin biosynthesis in lettuce (Lactuca sativa).
Article in Plant cell reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 124 citations in OpenAlex.
- Integrated multi-omics analysis reveals the regulatory mechanism of cryptochrome 1- mediated anthocyanin biosynthesis in Populus trichocarpa.BMC plant biology · 2026Article
- Genome-wide identification of the oat (Avena sativa L.) R2R3-MYB gene family and expression analysis under different abiotic stresses.BMC plant biology · 2026Article
- Glyceollin biosynthesis in a plant chassis engineered for isoflavone production.Nature chemical biology · 2025Article
- Systematic analysis of potato MYB family genes and their potential functions in anthocyanin biosynthesis.Scientific reports · 2025Article
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- Anthocyanin metabolites and related regulatory genes analysis in leaves of Acer Pseudosieboldianum mutant during different periods of color change.BMC genomics · 2025Article
- Red-Leafed Lettuces: Genetic Variation or Epigenetic Photomorphogenesis?Plants (Basel, Switzerland) · 2025Review
- R2R3 MYB Transcription Factor GhMYB201 Promotes Cotton Fiber Elongation via Cell Wall Loosening and Very-Long-Chain Fatty Acid Synthesis.International journal of molecular sciences · 2024Article
- Genome-Wide Identification and Characterization of the GRAS Gene Family in Lettuce Revealed That SilencingPlants (Basel, Switzerland) · 2024Article
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- LettuceGDB: The community database for lettuce genetics and omics.Plant communications · 2023Article
- Epicuticular wax accumulation and regulation of wax pathway gene expression during bioenergy Sorghum stem development.Frontiers in plant science · 2023Article
- Cloning and Functional Analysis ofGenes · 2022Article
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- Anthocyanin Biosynthesis Induced by MYB Transcription Factors in Plants.International journal of molecular sciences · 2022Review
- Integrated Metabolomic and Transcriptomic Analysis Reveals Differential Flavonoid Accumulation and Its Underlying Mechanism in Fruits of DistinctFoods (Basel, Switzerland) · 2022Article
- Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome ofCurrent research in food science · 2022Article
- Environmental and Genetic Factors Involved in Plant Protection-Associated Secondary Metabolite Biosynthesis Pathways.Frontiers in plant science · 2022Review
- Recent Advanced Metabolic and Genetic Engineering of Phenylpropanoid Biosynthetic Pathways.International journal of molecular sciences · 2021Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MYB transcription factors play important roles in the regulation of many secondary metabolites at the transcriptional level. We evaluated the possible roles of the Arabidopsis R2R3-MYB transcription factors in flavonoid biosynthesis because they are induced by UV-B irradiation but their associated phenotypes are largely unexplored. We isolated their genes by RACE-PCR, and performed transgenic approach and metabolite analyses in lettuce (Lactuca sativa). We found that one member of this protein family, AtMYB60, inhibits anthocyanin biosynthesis in the lettuce plant. Wild-type lettuce normally accumulates anthocyanin, predominantly cyanidin and traces of delphinidin, and develops a red pigmentation. However, the production and accumulation of anthocyanin pigments in AtMYB60-overexpressing lettuce was inhibited. Using RT-PCR analysis, we also identified the complete absence or reduction of dihydroflavonol 4-reductase (DFR) transcripts in AtMYB60- overexpressing lettuce (AtMYB60-117 and AtMYB60-112 lines). The correlation between the overexpression of AtMYB60 and the inhibition of anthocyanin accumulation suggests that the transcription factorAtMYB60 controls anthocyanin biosynthesis in the lettuce leaf. Clarification of the roles of the AtMYB60 transcription factor will facilitate further studies and provide genetic tools to better understand the regulation in plants of the genes controlled by the MYB-type transcription factors. Furthermore, the characterization of AtMYB60 has implications for the development of new varieties of lettuce and other commercially important plants with metabolic engineering approaches.
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