Evidence map›Paper›PMID 18317693›Full record

ArticleJournal of neuro-oncology2008

Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis.

Alexandros D Polydorides, Arie Perry, Mark A Edgar

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Alexandros D PolydoridesDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA. apolydor@med.umich.edu
Arie Perry
Mark A Edgar
Memorial Sloan Kettering Cancer Center · USUniversity of Michigan–Ann Arbor · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of large cell medulloblastoma with myogenic and melanotic differentiation arising in the cerebellar vermis of a 2-year-old boy and following an aggressive clinical course. Histologic and immunohistochemical features of this tumor include primitive neuronal, rhabdomyoblastic, and pigmented epithelial elements, along with large cell features. Immunohistochemical and molecular data (c-myc gene amplification and the presence of isochromosome 17q) support the contention that this histologically diverse tumor represents a pattern of medulloblastoma with striated muscle and pigmented epithelial differentiation, rather than a teratoma or a cerebellar variant of melanotic neuroectodermal tumor of infancy ('progonoma').

Indexed as

Cerebellar NeoplasmsMedulloblastomaAntigens, NeoplasmCell DifferentiationChild, PreschoolChromosomes, Human, Pair 17EpitheliumGlial Fibrillary Acidic ProteinHumansKaryotypingKeratinsMaleMelanoma-Specific AntigensMuscle DevelopmentNeoplasm ProteinsNeoplasms, Muscle TissueAntigens, NeoplasmGlial Fibrillary Acidic ProteinKeratinsMelanoma-Specific AntigensMYC protein, humanNeoplasm ProteinsProto-Oncogene Proteins c-myc

Identifiers

PMID18317693
OpenAlexW2057540403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.