ArticleEvidence-based complementary and alternative medicine : eCAM2008
Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.
Article in Evidence-based complementary and alternative medicine : eCAM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Efficacy and safety of AtusinBMC pulmonary medicine · 2025Trial
- Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016Trial
- Current Uses of Bromelain in Children: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Article
- Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism.Metabolic brain disease · 2019Article
- Cold Stimuli Facilitate Inflammatory Responses Through Transient Receptor Potential Melastatin 8 (TRPM8) in Primary Airway Epithelial Cells of Asthmatic Mice.Inflammation · 2018Article
- Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.Animal cells and systems · 2018Article
- Redistribution of adrenomedullary nicotinic acetylcholine receptor subunits and the effect on circulating epinephrine levels in a murine model of acute asthma.International journal of molecular medicine · 2017Article
- Potential role of bromelain in clinical and therapeutic applications.Biomedical reports · 2016Article
- Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation.The Journal of investigative dermatology · 2015Article
- Evaluation on the immunotherapy efficacies of synthetic peptide vaccines in asthmatic mice with group I and II allergens from Dermatophagoides pteronyssinus.International journal of clinical and experimental medicine · 2015Article
- Air-conditioner filters enriching dust mites allergen.International journal of clinical and experimental medicine · 2015Article
- Effects of canned pineapple consumption on nutritional status, immunomodulation, and physical health of selected school children.Journal of nutrition and metabolism · 2014Article
- Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination.Pediatric research · 2013Article
- Blockade of ankyrin repeat-rich membrane spanning protein modulates extracellular signal-regulated kinase expression and inhibits allergic inflammation in ovalbumin-sensitized mice.Biomedical reports · 2013Article
- Soft-X-ray-enhanced electrostatic precipitation for protection against inhalable allergens, ultrafine particles, and microbial infections.Applied and environmental microbiology · 2013Article
- Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALB/C Mice by Inhibiting Th2 Signal.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Tracking and treating activated T cells.Journal of drug delivery science and technology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Bromelain, a widely used pineapple extract with cysteine protease activity, has been shown to have immunomodulatory effects in a variety of immune system models. The purpose of the present study was to determine the effects of orally administered bromelain in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD). To establish AAD, female C57BL/6J mice were sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days. Mice were gavaged with either (phosphate buffered saline)PBS or 200 mg/kg bromelain in PBS, twice daily for four consecutive days, beginning 1 day prior to OVA aerosol challenge. Airway reactivity and methacholine sensitivity, bronchoalveolar lavage (BAL) cellular differential, Th2 cytokines IL-5 and IL-13, and lung histology were compared between treatment groups. Oral bromelain-treatment of AAD mice demonstrated therapeutic efficacy as evidenced by decreased methacholine sensitivity (P </= 0.01), reduction in BAL eosinophils (P </= 0.02) and IL-13 concentrations (P </= 0.04) as compared with PBS controls. In addition, oral bromelain significantly reduced BAL CD19+ B cells (P </= 0.0001) and CD8+ T cells (P </= 0.0001) in AAD mice when compared with controls. These results suggest that oral treatment with bromelain had a beneficial therapeutic effect in this murine model of asthma and bromelain may also be effective in human conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.