ArticleMolecular and cellular biology2008
Beta-catenin interacts with MyoD and regulates its transcription activity.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 85 citations in OpenAlex.
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- Exogenous hydrogen sulfide enhances myogenic differentiation of C2C12 myoblasts under high palmitate stress.Heliyon · 2024Article
- Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds.Cell communication and signaling : CCS · 2024Review
- The fibronectin concentration that optimally maintains porcine satellite cells.Animal bioscience · 2023Article
- Review
- Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology.Marine biotechnology (New York, N.Y.) · 2023Review
- Inhibition of GSK3β Promotes Proliferation and Suppresses Apoptosis of Porcine Muscle Satellite Cells.Animals : an open access journal from MDPI · 2022Article
- Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β.PLoS biology · 2022Article
- Dickkopf-1 Inhibition Reactivates Wnt/β-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo.International journal of molecular sciences · 2021Article
- The WNT/β-catenin dependent transcription: A tissue-specific business.WIREs mechanisms of disease · 2021Review
- Metabolic Contributions of Wnt Signaling: More Than Controlling Flight.Frontiers in cell and developmental biology · 2021Review
- From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells.Current opinion in cell biology · 2020Review
- Modulation of Klotho expression in injured muscle perturbs Wnt signalling and influences the rate of muscle growth.Experimental physiology · 2020Article
- Dual function of VGLL4 in muscle regeneration.The EMBO journal · 2019Article
- Cytoplasmic sequestration of the RhoA effector mDiaphanous1 by Prohibitin2 promotes muscle differentiation.Scientific reports · 2019Article
- Smad7:β-catenin complex regulates myogenic gene transcription.Cell death & disease · 2019Article
- β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.Development (Cambridge, England) · 2019Article
- TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes.The EMBO journal · 2019Article
- Epidermal growth factor can signal via β-catenin to control proliferation of mesenchymal stem cells independently of canonical Wnt signalling.Cellular signalling · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wnt regulation of muscle development is thought to be mediated by the beta-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that beta-catenin, not TCF/LEF, is required for muscle differentiation. We showed that beta-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when beta-catenin is deficient or the interaction between MyoD and beta-catenin is disrupted. These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.