ArticleThe Journal of surgical research2008
Mold-shaped, nanofiber scaffold-based cartilage engineering using human mesenchymal stem cells and bioreactor.
Article in The Journal of surgical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
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- Electrospun Polymers in Cartilage Engineering-State of Play.Frontiers in bioengineering and biotechnology · 2020Review
- Micro Vacuum Chuck and Tensile Test System for Bio-Mechanical Evaluation of 3D Tissue Constructed of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPS-CM).Micromachines · 2019Article
- Repair of Damaged Articular Cartilage: Current Approaches and Future Directions.International journal of molecular sciences · 2018Review
- Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage.Acta biomaterialia · 2017Article
- In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold.Tissue engineering. Part A · 2015Article
- A multicompartment holder for spinner flasks improves expansion and osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds.Tissue engineering. Part C, Methods · 2014Article
- Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering.Journal of biomedical materials research. Part A · 2014Article
- Clinical translation of stem cells: insight for cartilage therapies.Critical reviews in biotechnology · 2014Review
- Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix.Tissue engineering. Part A · 2013Article
- Fibroin and fibroin blended three-dimensional scaffolds for rat chondrocyte culture.Biomedical engineering online · 2013Article
- Stem cell-based tissue engineering approaches for musculoskeletal regeneration.Current pharmaceutical design · 2013Review
- The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds.Biomaterials · 2012Article
- Osteochondral tissue engineering: scaffolds, stem cells and applications.Journal of cellular and molecular medicine · 2012Review
- Novel Textile Scaffolds Generated by Flock Technology for Tissue Engineering of Bone and Cartilage.Materials (Basel, Switzerland) · 2012Article
- Nano-fibrous tissue engineering scaffolds capable of growth factor delivery.Pharmaceutical research · 2011Article
- Evaluating osteochondral defect repair potential of autologous rabbit bone marrow cells on type II collagen scaffold.Cytotechnology · 2011Article
- Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair.Osteoarthritis and cartilage · 2010Article
- Multifunctional hybrid three-dimensionally woven scaffolds for cartilage tissue engineering.Macromolecular bioscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMesenchymal stem cell (MSC)-based tissue engineering is a promising future alternative to autologous cartilage grafting. This study evaluates the potential of using MSCs, seeded into electrospun, biodegradable polymeric nanofibrous scaffolds, to engineer cartilage with defined dimensions and shape, similar to grafts used for subcutaneous implantation in plastic and reconstructive surgery. MATERIALS AND
methodsHuman bone marrow derived MSCs seeded onto nanofibrous scaffolds and placed in custom-designed molds were cultured for up to 42 days in bioreactors. Chondrogenesis was induced with either transforming growth factor-beta1 (TGF-beta1) alone or in combination with insulin-like growth factor-I (IGF-I).
resultsConstructs exhibited hyaline cartilage histology with desired thickness and shape as well as favorable tissue integrity and shape retention, suggesting the presence of elastic tissue. Time-dependent increase in cartilage matrix gene expression was seen in both types of culture: at Day 42, TGF-beta1/IGF-I treated cultures showed higher collagen Type 2 and aggrecan expression. Both culture conditions showed significant time-dependent increase in sulfated glycosaminoglycan and hydroxyproline contents. TGF-beta1/IGF-I-treated samples were significantly stiffer; with equilibrium compressive Young's modulus values reaching 17 kPa by Day 42.
conclusionsThe successful ex vivo development of geometrically defined cartilaginous construct using customized molding suggests the potential of cell-based cartilage tissue for reconstructive surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.