ArticleThe Journal of comparative neurology2008
Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia.
Article in The Journal of comparative neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Glutamate Transport and Preterm Brain Injury.Frontiers in physiology · 2019Review
- Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants.Molecular neurobiology · 2018Article
- Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.The Journal of membrane biology · 2016Article
- Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function.Translational psychiatry · 2016Article
- Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.The Journal of membrane biology · 2015Article
- Altered glutamatergic metabolism associated with punctate white matter lesions in preterm infants.PloS one · 2013Article
- Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development.The Journal of comparative neurology · 2012Article
- Modeling the encephalopathy of prematurity in animals: the important role of translational research.Neurology research international · 2012Article
- Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats.Journal of biomedical science · 2011Article
- The developing oligodendrocyte: key cellular target in brain injury in the premature infant.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2011Review
- The encephalopathy of prematurity: one pediatric neuropathologist's perspective.Seminars in pediatric neurology · 2009Article
- Regulation of glutamate transport in developing rat oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Regulation of glutamate transport and neuroinflammation in a term newborn rat model of hypoxic-ischaemic brain injury.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The major neuropathological correlate of cerebral palsy in premature infants is periventricular leukomalacia (PVL), a disorder of the immature cerebral white matter. Cerebral ischemia leading to excitotoxicity is thought to be important in the pathogenesis of this disorder, implying a critical role for glutamate transporters, the major determinants of extracellular glutamate concentration. Previously, we found that EAAT2 expression is limited primarily to premyelinating oligodendrocytes early in development and is rarely observed in astrocytes until >40 weeks. In this study, we analyzed the expression of EAAT2 in cerebral white matter from PVL and control cases. Western blot analysis suggested an up-regulation of EAAT2 in PVL compared with control cases. Single- and double-label immunocytochemistry showed a significantly higher percentage of EAAT2-immunopositive astrocytes in PVL (51.8% +/- 5.6%) compared with control white matter (21.4% +/- 5.6%; P = 0.004). Macrophages in the necrotic foci in PVL also expressed EAAT2. Premyelinating oligodendrocytes in both PVL and control cases expressed EAAT2, without qualitative difference in expression. The previously unrecognized up-regulation of EAAT2 in reactive astrocytes and its presence in macrophages in PVL reported here may reflect a response to either hypoxic-ischemic injury or inflammation.
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Registered trials
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