ArticleNeuroImage2008
Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy.
Article in NeuroImage, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
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- Associations between structural brain alterations and dysfunction across cognitive domains in cerebral small vessel disease: A systematic review and meta-analysis.Neuroimage. Reports · 2026Review
- Connectome reorganization associated with temporal lobe pathology and its surgical resection.Brain : a journal of neurology · 2024Article
- Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Exploring individual fixel-based white matter abnormalities in epilepsy.Brain communications · 2024Article
- Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Association Between Microstructural Asymmetry of Temporal Lobe White Matter and Memory Decline After Anterior Temporal Lobectomy.Neurology · 2022Article
- White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study.Brain : a journal of neurology · 2020Article
- Clinical utility of structural connectomics in predicting memory in temporal lobe epilepsy.Neurology · 2020Article
- Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Characterization and correlation of signal drift in diffusion weighted MRI.Magnetic resonance imaging · 2019Article
- Automated tractography in patients with temporal lobe epilepsy using TRActs Constrained by UnderLying Anatomy (TRACULA).NeuroImage. Clinical · 2017Article
- Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy.Brain : a journal of neurology · 2017Article
- Disrupted Structural and Functional Networks and Their Correlation with Alertness in Right Temporal Lobe Epilepsy: A Graph Theory Study.Frontiers in neurology · 2017Article
- Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy.Human brain mapping · 2016Article
- MEG Coherence and DTI Connectivity in mTLE.Brain topography · 2016Article
- Memory network plasticity after temporal lobe resection: a longitudinal functional imaging study.Brain : a journal of neurology · 2016Article
- White matter microstructure complements morphometry for predicting verbal memory in epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2014Article
- Repeatability of quantitative metrics derived from MR diffusion tractography in paediatric patients with epilepsy.The British journal of radiology · 2014Article
- Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging.NeuroImage. Clinical · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
introductionTemporal lobe epilepsy (TLE) is associated with disrupted memory function. The structural changes underlying this memory impairment have not been demonstrated previously with tractography.
methodsWe performed a tractography analysis of diffusion magnetic resonance imaging scans in 18 patients with unilateral TLE undergoing presurgical evaluation, and in 10 healthy controls. A seed region in the anterior parahippocampal gyrus was selected from which to trace the white matter connections of the medial temporal lobe. A correlation analysis was carried out between volume and mean fractional anisotropy (FA) of the connections, and pre-operative material specific memory performance.
resultsThere was no significant difference between the left and right sided connections in controls. In the left TLE patients, the connected regions ipsilateral to the epileptogenic region were found to be significantly reduced in volume and mean FA compared with the contralateral region, and left-sided connections in control subjects. Significant correlations were found in left TLE patients between left and right FA, and verbal and non-verbal memory respectively.
conclusionTractography demonstrated the alteration of white matter pathways that may underlie impaired memory function in TLE. A detailed knowledge of the integrity of these connections may be useful in predicting memory decline in chronic temporal lobe epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.