ArticleRespiratory physiology & neurobiology2008
Prediction of the rate of uptake of carbon monoxide from blood by extravascular tissues.
Article in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- A carbon monoxide cycle drives carbon monoxide uptake and poisoning.Physiological reports · 2026Article
- Carboxyhemoglobin half-life toxicokinetic profiles during and after normobaric oxygen therapy: On a swine model.Toxicology reports · 2024Article
- Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review.International journal of environmental research and public health · 2020Review
- The Diagnosis and Treatment of Carbon Monoxide Poisoning.Deutsches Arzteblatt international · 2018Review
- Rapid elimination of CO through the lungs: coming full circle 100 years on.Experimental physiology · 2011Article
- A mathematical modeling approach to risk assessment for normal and anemic women chronically exposed to carbon monoxide from biomass-fueled cookstoves.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Uptake of environmental carbon monoxide (CO) via the lungs raises the CO content of blood and of myoglobin (Mb)-containing tissues, but the blood-to-tissue diffusion coefficient for CO (DmCO) and tissue CO content are not easily measurable in humans. We used a multicompartment mathematical model to predict the effects of different values of DmCO on the time courses and magnitudes of CO content of blood and Mb-containing tissues when various published experimental studies were simulated. The model enhances our earlier model by adding mass balance equations for oxygen and by dividing the muscle compartment into two subcompartments. We found that several published experimental findings are compatible with either fast or slow rates of blood-tissue transfer of CO, whereas others are only compatible with slow rates of tissue uptake of CO. We conclude that slow uptake is most consistent with all of the experimental data. Slow uptake of CO by tissue is primarily due to the very small blood-to-tissue partial pressure gradients for CO.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.