ReviewNanomedicine : nanotechnology, biology, and medicine2008
Nonviral gene transfection nanoparticles: function and applications in the brain.
Review in Nanomedicine : nanotechnology, biology, and medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 82 citations in OpenAlex.
- Nanotechnology: A Promising Targeted Drug Delivery System for Brain Tumours and Alzheimer's Disease.Current medicinal chemistry · 2023Review
- mRNA, a Revolution in Biomedicine.Pharmaceutics · 2021Review
- Improving therapeutic potential of non-viral minimized DNA vectors.Cell & gene therapy insights · 2020Article
- In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture.Molecules (Basel, Switzerland) · 2020Article
- Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine.Nanomaterials (Basel, Switzerland) · 2019Review
- A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: results of an in vivo study.Journal of materials science. Materials in medicine · 2019Article
- Urological technology: where will we be in 20 years' time?Therapeutic advances in urology · 2018Review
- Non-agglomerated silicon-organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties.Beilstein journal of nanotechnology · 2018Article
- Article
- Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance.Pharmaceutical research · 2015Review
- Nanoparticles in the brain: a potential therapeutic system targeted to an early defect observed in many neurodegenerative diseases.Pharmaceutical research · 2013Review
- Delivery systems and local administration routes for therapeutic siRNA.Pharmaceutical research · 2013Review
- Melittin-grafted HPMA-oligolysine based copolymers for gene delivery.Biomaterials · 2013Article
- Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms.Pain · 2012Article
- Gold nanorod--siRNA induces efficient in vivo gene silencing in the rat hippocampus.Nanomedicine (London, England) · 2011Article
- Nanotechnology in urology.The Urologic clinics of North America · 2009Review
- Locally induced neural stem cells/pluripotent stem cells for in vivo cell replacement therapy.International archives of medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In vivo transfer and expression of foreign genes allows for the elucidation of functions of genes in living organisms and generation of disease models in animals that more closely resemble the etiology of human diseases. Gene therapy holds promise for the cure of a number of diseases at the fundamental level. Synthetic "nonviral" materials are fast gaining popularity as safe and efficient vectors for delivering genes to target organs. Not only can nanoparticles function as efficient gene carriers, they also can simultaneously carry diagnostic probes for direct "real-time" visualization of gene transfer and downstream processes. This review has focused on the central nervous system (CNS) as the target for nonviral gene transfer, with special emphasis on organically modified silica (ORMOSIL) nanoparticles developed in our laboratory. These nanoparticles have shown robust gene transfer efficiency in brain cells in vivo and allowed to investigate mechanisms that control neurogenesis as well as neurodegenerative disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.