Evidence map›Paper›PMID 18313628›Full record

ReviewHeart failure clinics2008

Exercise intolerance.

Dalane W Kitzman, Leanne Groban

Open access · greenAbstract readReview
In one paragraph

Review in Heart failure clinics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Article
  8. CHAScientific reports · 2018
    Observational
  9. Adenosine ADrug design, development and therapy · 2017
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2011
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dalane W KitzmanSection of Cardiology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. dkitzman@wfubmc.edu
Leanne Groban
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
Growth Hormone, Angiotensin II, and Cardiac AgingK08AG026764 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 2005 to 2009
$858k
NIA NIH HHS K08 AG026764NIA NIH HHS K08-AG026764NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG21332NIA NIH HHS R37 AG018915NIA NIH HHS R37-AG18915
6 · The paper itself

Abstract

Exercise intolerance is the primary symptom of chronic diastolic heart failure. It is part of the definition of heart failure and is intimately linked to its pathophysiology. Further, exercise intolerance affects the diagnosis and prognosis of heart failure. In addition, understanding the mechanisms of exercise intolerance can lead to developing and testing rational treatments for heart failure. This article focuses on the fundamental principles of exercise physiology and on the assessment, pathophysiology, and potential treatment of exercise intolerance in diastolic heart failure.

Indexed as

Exercise ToleranceChronic DiseaseDiastoleHeart FailureHeart RateHumansMuscle, SkeletalPrognosisStroke Volume

Identifiers

PMID18313628
PMCPMC2700357
OpenAlexW4211221586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.